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- Young, I.T. (author), Gerbrands, J.J. (author), Van Vliet, L.J. (author) book 1998
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- Netten, H. (author), Young, I.T. (author), Prins, M. (author), Van Vliet, L.J. (author), Tanke, H. (author), Vrolijk, H. (author), Sloos, W. (author) conference paper 1994
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- Van Den Doel, L.R. (author), Young, I.T. (author), Van Vliet, L.J. (author) conference paper 2001
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- Van den Doel, L.R. (author), Vellekoop, M.J. (author), Sarro, P.M. (author), Moerman, R. (author), Frank, J. (author), Van Dedem, G. (author), Hjelt, K.T. (author), Van Vliet, L.J. (author), Young, I.T. (author) conference paper 2000
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Dietrich, H.R.C. (author), Van den Doel, R.L. (author), Hoyer, W. (author), Van Oel, W. (author), Liqui Lung, G. (author), Garini, Y. (author), Jovin, T. (author), Young, I.T. (author)In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein ?-synuclein. We describe the motivation for...conference paper 2005
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- Van den Doel, L.R. (author), Van Vliet, L.J. (author), Hjelt, K.T (author), Vellekoop, M.J. (author), Gromball, F. (author), Korvink, J.G. (author), Young, I.T. (author) conference paper 2000
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Dietrich, H.R.C. (author), Young, I.T. (author), Garini, Y. (author)The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact...conference paper 2006
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Garini, Y. (author), Kutchoukov, V.G. (author), Bossche, A. (author), Alkemade, P.F.A. (author), Docter, M.W. (author), Verbeek, P.W. (author), Van Vliet, L.J. (author), Young, I.T. (author)Recently, an extraordinary transmission of light through small holes (<200 nm) in a thin metallic film has been described. This phenomenon has been shown to be the result of the photon-plasmon interaction in thin films where a periodic structure (such as a set of holes) is embedded in the film. One of the extraordinary results is that the beam...conference paper 2004
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Parikesit, G.O.F. (author), Kutchoukov, V.G. (author), Bossche, A. (author), Young, I.T. (author), Garini, Y. (author)We report on the progress of a novel nanofluidic device for detecting and manipulating single molecules in solution. This paper discusses the development of an earlier proposed molecule separation method, where electrokinetic forces separate different molecules based on their masses and charges. Optical imaging using confocal microscopy is...conference paper 2005
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Young, I.T. (author), Garini, Y. (author), Dietrich, H.R.C. (author), Van Oel, W. (author), Liqui Lung, G. (author)Traditional light sources for fluorescence microscopy have been mercury lamps, xenon lamps, and lasers. These sources have been essential in the development of fluorescence microscopy but each can have serious disadvantages: lack of near monochromaticity, heat generation, cost, lifetime of the light source, and possible distortions due to...conference paper 2004
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- Van den Doel, L.R. (author), Hjelt, K.T. (author), Young, I.T. (author), Van Vliet, L.J. (author) conference paper 1999
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Young, I.T. (author), Garini, Y. (author), Vermolen, B. (author), Liqui Lund, G. (author), Brouwer, G. (author), Hendrichs, S. (author), El Morabit, M. (author), Spoelstra, J. (author), Wilhelm, E. (author), Zaal, M. (author)While fluorescence microscope systems remains an essential tool in modern biology and medical work, no compact instrumentation has been developed for the rapid calibration of such systems. Almost invariably results are presented in terms of the [AU], "arbitrary units". To remedy this situation we have developed a small, portable instrument - the...conference paper 2006
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Vermolen, B.J. (author), Young, I.T. (author), Chuang, A. (author), Wark, L. (author), Chuang, T. (author), Mai, S. (author), Garini, Y. (author)Quantitative analysis in combination with fluorescence microscopy calls for innovative digital image measurement tools. We have developed a three-dimensional tool for segmenting and analyzing FISH stained telomeres in interphase nuclei. After deconvolution of the images, we segment the individual telomeres and measure a distribution parameter we...conference paper 2005
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- Young, I.T. (author), Van Vliet, L.J. (author), Van Ginkel, M. (author) conference paper 2000
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Docter, M.W. (author), Young, I.T. (author), Kutchoukov, V.G. (author), Bossche, A. (author), Alkemade, P.F.A. (author), Garini, Y. (author)When light passes through a hole smaller than the wavelength of the light, the transmission is very low and the light is diffracted. This however changes if holes are arranged in a periodic array on metal. In that case the light couples to surface plasmons; this results in enhanced transmission, spectral selection and a small angular diffraction...conference paper 2005
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Dietrich, H.R.C. (author), Vermolen, B.J. (author), Rieger, B. (author), Young, I.T. (author), Garini, Y. (author)Single-molecule techniques continue to gain in popularity in research disciplines such as the study of intermolecular interactions. These techniques provide information that otherwise would be lost by using bulk measurements that deal with a large number of molecules. We describe in this report the motion of tethered DNA molecules that have been...conference paper 2007
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- Young, I.T. (author), Zagers, R. (author), Van Vliet, L.J. (author), Mullikin, J. (author), Boddeke, F. (author), Netten, H. (author) conference paper 1993
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- Dijk, J. (author), De Ridder, D. (author), Verbeek, P.W. (author), Walraven, J. (author), Young, I.T. (author), Van Vliet, L.J. (author) conference paper 1999
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Dietrich, H.R.C. (author), Young, I.T. (author), Garini, Y. (author)The intense research in proteomics is demanding for fast, reliable and easy-to-use methods in order to study the proteome. In this proceeding we report the development of such a novel research tool based on spectral imaging and Resonance Light Scattering gold particles. This method will allow the study of DNA-protein interactions. We suggest a...conference paper 2005
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Parikesit, G.O.F. (author), Kutchoukov, V.G. (author), Van Oel, W. (author), Lung, G.L. (author), Bossche, A. (author), Young, I.T. (author), Garini, Y. (author)We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are...conference paper 2004