Searched for: mods_note_programme_s%3A%22Mechanical%255C+Engineering%255C+%257C%255C+Micro%255C+and%255C+Nano%255C+Engineering%22
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Davidov, Lyuben (author)There is a growing demand for precision and high-quality optical objectives and lenses due to their numerous advantages and uses. The market for high precision objective lenses has tremendous potential for development and is a sector that is expanding quickly. <br/><br/>Measuring the aberrations of optical systems is an essential step in the...master thesis 2023
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Jaarsma, Victor (author)This research investigates the implementation of electroactive polymer (EAP) actuators for the propulsion of a robotic fish. An efficient manufacturing procedure is developed which uses a combination of stencil printing and inkjet printing to manufacture P(VDF-TrFE-CTFE) actuators. The influence of layer thicknesses is studied theoretically and...master thesis 2023
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Elhassan, Shiemaa (author)An Organ-on-a-Chip (OoC) is a microfluidic device that mimics an organ function on a chip. The goal of the OoC technology is to create disease models of various organs and use them to minimise animal testing. One of the important parameters to maintain the cells/tissues on the OoC is the temperature, typically at 37 °C. Usually, cell culture...master thesis 2023
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Schilperoort, Frank (author)Electret transducers utilize the electric field generated by an electret, a dielectric with a quasi-permanent embedded charge, to induce charge on an electrode. When the electret is moved relative to the electrode, the induced charge magnitude on the electrode changes, generating a current that can be used to convert mechanical energy into...master thesis 2022
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de Winter, Jikke (author)Biosensing properties like mass, density and stiffness on a single cell level can help diagnose diseases. Mass sensing of cells and subcellular components is typically performed with resonant microstructures. Recently such microstructures were fabricated using an emerging 3D printing technique called two-photon polymerization (2PP) contrary to...master thesis 2022
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Hulsman, Filippus (author)The research investigates the creation of an end-effector capable of pick-and-placing thin laminates of various materials. The chosen end-effector design induces a pressure differential with a membrane, and is capable to achieve a large switching force for various delicate and geometric complex laminates. The concept utilizes an array of holes,...master thesis 2022
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den Boer, Sophie (author)In vitro models are fundamental in the study of cell behaviour, the physiological function of organs, and their response to drugs and toxins. However, the shortage of accurate and reliable in vitro models calls for the development of in vitro lung models that better recapitulate lung physiology and pathology. Lung-on- a-chip models are promising...master thesis 2022
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Horsthuis, Jan (author)Capillary self-alignment shows the potential to keep small components aligned using soft liquid contact when disturbed by external forces. Whilst this concept has been promising, mostly static situations have been investigated, making it unclear how a receptor-droplet-chip (RDC) configuration behaves dynamically and where its stability limits...master thesis 2022
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Blankespoor, Maarten (author)The processes that take place within cells are complex. Single-cell analysis is a method that is employed to gain further understanding of the working mechanisms on a single-cellular level. The controlled transport of substances through the cell membrane is important for studying the behaviour and responses of single living cells. Femtopipettes...master thesis 2022
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Roos, Brian (author)Microglia, the resident macrophages of the central nervous system, are key players in neuroinflammation and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. These cells represent promising cellular targets for therapeutic intervention, therefore a detailed cellular biological knowledge of microglia is of paramount importance....master thesis 2021
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Barin, Nastaran (author)Glioblastoma (GBM) is the most aggressive and malignant brain tumor with no effective treatment available so far. A major obstacle in GBM research is the lack of reliable in vitro models that can mimic the tumor cellular environment. The goal of this study was to develop a 3D-engineered scaffold as a new cell culture model capable of providing a...master thesis 2021
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van Altena, Pieter (author)Facioscapulohumeral muscle dystrophy (FSHD) is the third most common muscle disease in the world. No cure has been found for FSHD, and current treatments focus on alleviating the symptoms. The disease is caused by a genetic error in 1/1000 - 1/200 of the nuclei in a multinucleated skeletal muscle cell. Studying that specific nucleus, by removing...master thesis 2021
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Ajroemjan, Wahhe (author)The packaging of a microchip affects its size, performance and cost. With advanced packaging, more efficient and smaller microchips can be produced. For this, advanced packaging stepper systems are used, which are lithography machines with a highly optimized projection lens system, that use a powerful light source. The projection lens system for...master thesis 2021
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Yengül, Damla (author)A research gap exists in a targeted drug delivery into the brain with an implant placed on the outer surface of the cerebral cortex. If an implant with spatial control that can release drugs to a target location can be developed, it will provide efficient treatment opportunities for a variety of brain disorders such as strokes. One of the...master thesis 2021
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Zabreen Nissar, Zabreen (author)In vitro models are used for studying the physiological function of an organ, disease modelling and drug testing. Over the last decade, since their first commercial introduction, organ-on-a-chip (OOC) technology has proved to be able to recreate aspects of organ function that conventional in vitro models, such as cell culture wells and cell...master thesis 2021
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Akolawala, Qais (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. Novel <i>in-vitro</i> methods for the assessment of cancer response to drugs and radiation are being developed. Compared to two-dimensional cell culture, three-dimensional cellular microenvironments provide a model closer to the <i>in-vivo</i> situation. In...master thesis 2021
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Tuztaşi, Halis (author)Diamond is known for its outstanding material properties, including highest hardness, excellent chem ical resistance and high thermal conductivity. Diamond, which is normally formed in high pressure and temperature environments, can also be produced as polycrystalline thin films in reduced pressure environments through chemical vapor deposition...master thesis 2021
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Elschot, Sanne (author)Dielectric elastomer actuators (DEAs) are a type of soft actuators that consist of a dielectric elastomer membrane, covered with an electrode on the top and the bottom. When applying a potential, the opposite charges on the electrodes induce an electrostatic force which squeezes the elastomer, causing it to expand. This expansion can be used as...master thesis 2021
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van Reeuwijk, Matthijs (author)Current technology of Organ-on-Chips allows investigation of human cells outside the body including a microfluidic medium flow. Control of oxygen in this microfluidic flow is required to mimic the situation as in the human liver (physiological) or to create temporary low oxygen concentrations (hypoxia). In this research, a gas exchanger module...master thesis 2021
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Aalbers, Sarah (author)The Organ on Chip (OoC) market is fast-growing and has the promise to drastically reduce the cost of developing drugs and the need for animal testing. However, the growth could be obstructed by the difficulties of scaling up production of developed prototypes. Most OoC prototypes are not suited for mass production because of the material used,...master thesis 2021
Searched for: mods_note_programme_s%3A%22Mechanical%255C+Engineering%255C+%257C%255C+Micro%255C+and%255C+Nano%255C+Engineering%22
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