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Restrepo Sierra, A.M. (author)Life, the most complex and admirable machine that one could think of has evolved over billions of years to display a beautiful variety of mechanisms that keep cells adapting, self-maintaining, reproducing, and evolving. If we think about it, what is this magic? What are the mechanisms behind life’s origins and wonderful coordination? Attracted...doctoral thesis 2024
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Kok, R.N.U. (author)How does the small intestine maintain itself? What mechanism does it use to achieve<br/>homeostasis, and how optimal is this mechanism? We approached these questions<br/>mainly using cell tracking in organoids, for which we developed new cell trackers.<br/>We found that the intestinal crypt uses a surprisingly simple and effective strategy.<br/...doctoral thesis 2024
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Tišma, M. (author)This thesis explores the mechanisms that underlie chromosome organization in bacteria. Bacteria are considered amongst the simplest living organisms on our planet. They lack the cellular organization found in other domains of life (Archaea or Eukaryotics) and often have simpler life cycles. Over the past decade, we gained increasing knowledge...doctoral thesis 2024
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Recalde Moreno Del Rocio, M.D.R. (author)The global market for the wastewater treatment industry has been compelled to devise new concepts due to several factors. Currently, approximately 80% of untreated wastewater is discharged worldwide. The conventional technology for municipal solid waste treatment, which has been in use for over a century, is only partially effective in terms of...doctoral thesis 2024
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Amladi, Amogh (author), Venkataraman, V. (author), Woudstra, T. (author), Aravind, P.V. (author)Energy storage is vital for the energy transition, enabling reliable power grids based on intermittent renewables. Reversible solid oxide cell (rSOC) technology is promising for seasonal energy storage. The novel finding from this work is that optimised air recirculation for rSOC in endothermic electrolyser mode leads to efficiency being...journal article 2024
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Azevedo Vasconcelos, A.C. (author), Valiya Valappil, S. (author), Schott, D.L. (author), Jovanova, J. (author), Aragon, A.M. (author)Underwater noise resulting from the monopile driving process can cause severe damage to marine wildlife, such as hearing injury, behavioral disturbance, or even death. Although current noise-attenuation techniques used in this process have shown a significant noise reduction at high frequency ranges, mitigating low-frequency noise is still...journal article 2024
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Zhang, Zhenya (author), Mao, Jia (author), Wei, Houyu (author), Cheng, Chuanxiao (author), Liu, Zhengxuan (author)Proton exchange membrane fuel cells offer promising clean energy solutions for various applications. However, their performance relies heavily on the properties of the microporous layer, which plays a crucial role in transporting and distributing the components in the fuel cell. To date, the potential for optimising the microporous layer...journal article 2024
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Hoekstra, Mirjam E. (author), Slagter, Maarten (author), Urbanus, Jos (author), Toebes, Mireille (author), Slingerland, Nadine (author), de Rink, Iris (author), Kluin, Roelof J.C. (author), Nieuwland, Marja (author), Wessels, L.F.A. (author)Cells in the tumor microenvironment (TME) influence each other through secretion and sensing of soluble mediators, such as cytokines and chemokines. While signaling of interferon γ (IFNγ) and tumor necrosis factor α (TNFα) is integral to anti-tumor immune responses, our understanding of the spatiotemporal behavior of these cytokines is...journal article 2024
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Chrafih, Younes (author), Al-Hattab, Mohamed (author), El Boubekri, A. (author), Rahmani, Khalid (author), Bajjou, Omar (author), Basyooni, Mohamed A. (author)Tandem solar cells have a wider photon absorption range, allowing them to provide better efficiency than single-junction SC. The upper cell absorbs high-energy photons, while the lower cell absorbs low-energy filtered photons. However, in order to obtain affordable, efficient, and long-lasting SC, the absorber layers of the top and bottom...journal article 2024
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El Ghazi, Haddou (author), Eker, Yasin Ramazan (author), En-nadir, Redouane (author), Ahmed, Shrouk Eid Zaki (author), Basyooni, Mohamed A. (author)The paper deals with the conception and feasibility of the device structure based on the optimized PIN-(In, Ga)N homojunction solar cells. A new and efficient model combining the most realistic ones considering the impacts of band gap narrowing, collection efficiency, Shockley-Read-Hall recombination, and interface polarization is proposed to...journal article 2024
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Berkhout, J. B. (author), Poormoghadam, D. (author), Yi, C. (author), Kalsbeek, A. (author), Meijer, O. C. (author), Mahfouz, A.M.E.T.A. (author)The hypothalamic paraventricular nucleus (PVN) is a highly complex brain region that is crucial for homeostatic regulation through neuroendocrine signaling, outflow of the autonomic nervous system, and projections to other brain areas. In the past years, single-cell datasets of the hypothalamus have contributed immensely to the current...journal article 2024
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Useche, Sergio A. (author), Alonso, Francisco (author), Faus, Mireia (author), Trejo, Arturo Cervantes (author), Castaneda, Isaac (author), Oviedo-Trespalacios, O. (author)Introduction. Technological advancements have the potential to enhance people’s quality of life, but their misuse can have a detrimental impact on safety. A notable example is the escalating issue of distracted driving resulting from the use of mobile phones behind the wheel, leading to severe crashes and injuries. Despite these concerns,...journal article 2024
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...review 2024
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Michielsen, L.C.M. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)Most regulatory elements, especially enhancer sequences, are cell population-specific. One could even argue that a distinct set of regulatory elements is what defines a cell population. However, discovering which non-coding regions of the DNA are essential in which context, and as a result, which genes are expressed, is a difficult task. Some...journal article 2024
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Balzani, Daniel (author), Heinlein, A. (author), Klawonn, Axel (author), Knepper, Jascha (author), Nurani Ramesh, Sharan (author), Rheinbach, Oliver (author), Saßmannshausen, Lea (author), Uhlmann, Klemens (author)A computational framework is presented to numerically simulate the effects of antihypertensive drugs, in particular calcium channel blockers, on the mechanical response of arterial walls. A stretch-dependent smooth muscle model by Uhlmann and Balzani is modified to describe the interaction of pharmacological drugs and the inhibition of smooth...journal article 2024
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Yarali, E. (author), Klimopoulou, M. (author), David, M.K. (author), Boukany, P. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)The Poisson's ratio and elastic modulus are two parameters determining the elastic behavior of biomaterials. While the effects of elastic modulus on the cell response is widely studied, very little is known regarding the effects of the Poisson's ratio. The micro-architecture of meta-biomaterials determines not only the Poisson's ratio but...journal article 2024
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Kuruganti, V.V. (author), Isabella, O. (author), Mihailetchi, Valentin D. (author)Interdigitated back contact (IBC) architecture can yield among the highest silicon wafer-based solar cell conversion efficiencies. Since both polarities are realized on the rear side, there is a definite need for a patterning step. Some of the common patterning techniques involve photolithography, inkjet patterning, and laser ablation. This...journal article 2024
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van den Broek, M.A. (author), Ortiz Merino, R.A. (author), Bennis, N.X. (author), Wronska, A.K. (author), Else-Hassing, J. (author), Daran-Lapujade, P.A.S. (author), Daran, J.G. (author)The biobased-economy aims to create a circular biotechnology ecosystem to transition from a fossil fuel-based to a sustainable industry based on biomass. For this, new microbial cell-factories are essential. We present the draft genome of the CEN.PK-derived Saccharomyces cerevisiae SpyCas9 expressing strain (IMX2600), that serve as chassis of...journal article 2024
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Zhang, Zhenya (author), Mao, Jia (author), Liu, Zhengxuan (author)In response to the growing global demand for clean and sustainable energy solutions, proton exchange membrane fuel cells (PEMFCs) have emerged as vital components in diverse decarbonization strategies. Despite their increasing importance, a comprehensive synthesis of recent advancements, challenges, and future prospects in thermal and water...journal article 2024
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Quispe Haro, Juan José (author), Chen, Fei (author), Los, R. (author), Shi, Shuqi (author), Sun, Wenjun (author), Chen, Yong (author), Idema, T. (author), Wegner, Seraphine V. (author)The transition of bacteria from an individualistic to a biofilm lifestyle profoundly alters their biology. During biofilm development, the bacterial cell-cell adhesions are a major determinant of initial microcolonies, which serve as kernels for the subsequent microscopic and mesoscopic structure of the biofilm, and determine the resulting...journal article 2024