- document
-
Dell'Anna, D. (author), Aydemir, Fatma Başak (author), Dalpiaz, Fabiano (author)Context: Automated classifiers, often based on machine learning (ML), are increasingly used in software engineering (SE) for labelling previously unseen SE data. Researchers have proposed automated classifiers that predict if a code chunk is a clone, if a requirement is functional or non-functional, if the outcome of a test case is non...journal article 2023
- document
-
Shome, A. (author), Cruz, Luis (author), van Deursen, A. (author)Visualisations drive all aspects of the Machine Learning (ML) Development Cycle but remain a vastly untapped resource by the research community. ML testing is a highly interactive and cognitive process which demands a human-in-the-loop approach. Besides writing tests for the code base, bulk of the evaluation requires application of domain...conference paper 2023
- document
-
Ardıç, B.A. (author), Zaidman, A.E. (author)Software testing is generally acknowledged to be an important weapon in the arsenal of software engineers to produce correct and reliable software systems. However, given the importance of the topic, little is known about where software engineers get their testing knowledge and skills from. Is this through (higher) education, training...conference paper 2023
- document
-
Bennis, N.X. (author), Anderson, Jonah P. (author), Kok, Siebe M.C. (author), Daran, J.G. (author)ErCas12a is a class 2 type V CRISPR-Cas nuclease isolated from Eubacterium rectale with attractive fundamental characteristics, such as RNA self-processing capability, and lacks reach-through royalties typical for Cas nucleases. This study aims to develop a ErCas12a-mediated genome editing tool applicable in the model yeast Saccharomyces...journal article 2023
- document
-
Song, Y. (author)In the past decade, human digital twins (HDTs) attracted attention in both digital twin (DT) applications and beyond. In this paper, we discuss the concept and the development of HDTs, focusing on their architecture, key enabling technologies, and (potential) applications. Based on the literature, we identify personal data, model, and interface...review 2023
- document
-
Hai, R. (author), Koutras, C. (author), Quix, Christoph (author), Jarke, Matthias (author)Data lakes are becoming increasingly prevalent for Big Data management and data analytics. In contrast to traditional 'schema-on-write' approaches such as data warehouses, data lakes are repositories storing raw data in its original formats and providing a common access interface. Despite the strong interest raised from both academia and...journal article 2023
- document
-
Voltage Imaging with Engineered Proton-Pumping Rhodopsins: Insights from the Proton Transfer PathwayMeng, X. (author), Ganapathy, S. (author), van Roemburg, Lars (author), Post, M.G. (author), Brinks, D. (author)Voltage imaging using genetically encoded voltage indicators (GEVIs) has taken the field of neuroscience by storm in the past decade. Its ability to create subcellular and network level readouts of electrical dynamics depends critically on the kinetics of the response to voltage of the indicator used. Engineered microbial rhodopsins form a...review 2023
- document
-
Aldulijan, Ibrahim (author), Beal, Jacob (author), Billerbeck, Sonja (author), Bouffard, Jeff (author), Chambonnier, Gaël (author), Ntelkis, Nikolaos (author), Guerreiro, Isaac (author), Holub, M. (author), Ross, Paul (author)Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes...review 2023
- document
-
Ganapathy, S. (author), Meng, X. (author), Mossel, D.D.M. (author), Jagt, Mels (author), Brinks, D. (author)Genetically encoded voltage indicators, particularly those based on microbial rhodopsins, are gaining traction in neuroscience as fluorescent sensors for imaging voltage dynamics with high-spatiotemporal precision. Here we establish a novel genetically encoded voltage indicator candidate based on the recently discovered subfamily of the...journal article 2023
- document
-
Ribas, Francesca (author), Portos-Amill, Laura (author), Falqués, Albert (author), Arriaga, Jaime (author), Marcos, Marta (author), Ruessink, Gerben (author)Mean sea-level rise (MSLR) will induce shoreline recession, increasing the stress on coastal systems of high socio-economic and environmental values. Localized mega-nourishments are meant to alleviate erosion problems by diffusing alongshore over decades and thus feeding adjacent beaches. The 21-st century morphological evolution of the...journal article 2023
- document
-
Mitici, M.A. (author), de Pater, I.I. (author), Barros, Anne (author), Zeng, Zhiguo (author)The increasing availability of condition-monitoring data for components/systems has incentivized the development of data-driven Remaining Useful Life (RUL) prognostics in the past years. However, most studies focus on point RUL prognostics, with limited insights into the uncertainty associated with these estimates. This limits the...journal article 2023
- document
-
Ratz, Raphael (author), Marchal Crespo, L. (author)Whole-hand haptic rendering could lead to more naturalistic and intuitive virtual hand-object interactions, which could be especially beneficial for applications such as sensorimotor robotic neurorehabilitation. However, the majority of previously proposed whole-hand haptic rendering algorithms rely on effortful custom implementations or are...conference paper 2023
- document
-
Liem, C.C.S. (author), Demetriou, A.M. (author)So far, the relationship between open science and software engineering expertise has largely focused on the open release of software engineering research insights and reproducible artifacts, in the form of open-access papers, open data, and open-source tools and libraries. In this position paper, we draw attention to another perspective:...conference paper 2023
- document
-
Dostanic, M. (author), Windt, Laura (author), Wiendels, Maury (author), van Meer, Berend J. (author), Mummery, Christine L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)We present a novel design of elastic micropillars for tissue self-assembly in engineered heart tissue (EHT) platforms. The innovative tapered profile confines reproducibly the tissue position along the main micropillar axis, increasing the accuracy of tissue contraction force measurement. Polydimethylsiloxane-based pillars were designed and...conference paper 2023
- document
-
Al-Kaswan, A. (author), Ahmed, Toufique (author), Izadi, M. (author), Sawant, Anand Ashok (author), Devanbu, Premkumar (author), van Deursen, A. (author)Binary reverse engineering is used to understand and analyse programs for which the source code is unavailable. Decompilers can help, transforming opaque binaries into a more readable source code-like representation. Still, reverse engineering is difficult and costly, involving considering effort in labelling code with helpful summaries....conference paper 2023
- document
-
Sattari, R. (author), van Zeijl, H.W. (author), Zhang, Kouchi (author)This study presents a novel manufacturing process and design towards an enhanced sensitivity of an in-package relative humidity sensor. The device comprises multi-width interdigital electrodes which make oxide pillars appear during wet chemical etching in the fabrication process. Those oxide pillars appear only in wider areas while completely...conference paper 2023
- document
-
van Dam, Tim (author), Izadi, M. (author), van Deursen, A. (author)Transformer-based pre-trained models have recently achieved great results in solving many software engineering tasks including automatic code completion which is a staple in a developer’s toolkit. While many have striven to improve the code-understanding abilities of such models, the opposite – making the code easier to understand – has not been...conference paper 2023
- document
-
Carrete, Israel A. (author), Ghodrat, S. (author), Scherer, Diana (author), Karana, E. (author)Plant root growth can be altered by introducing obstacles in the path of growth. This principle is used in design to produce planar grid structures composed of interweaving roots. The Engineered Plant Root Materials (EPRMs) grown with this method have the potential to serve as environmentally sensitive alternatives for conventional materials,...journal article 2023
- document
-
Montagne, A.J.M. (author)Many people consider analog electronic circuit design complex. This is because designers can achieve the desired performance of a circuit in many ways. Together, theoretical concepts, circuit topologies, electronic devices, their operating conditions, and the system's physical construction constitute an enormous design space in which it is easy...book 2023
- document
- Palmisano, Fabrizio (author), Rus, Laurent (author), Terwel, K.C. (author) abstract 2023