Extrusion-based 3D printing of biodegradable porous iron for bone substitution

The treatment of large bone injuries continues to be challenging partially due to the limited quantity and quality of bone-replacing materials. Iron (Fe) and its alloys have been developed as a group of load-bearing biomaterials. Recent advances in additive manufacturing (AM) have enhanced the potential of Fe-based biomaterials as biodegradable...

Multifunctional implants Prevention is better than cure

Millions of people around the globe receive orthopedic implants every year. These implants help people to regain their mobility and contribute tremendously to improve the quality of life. However, a significant number of patients suffer from complications, such as implant associated infections (IAI) and aseptic loosening. The number of...

Nanofabrication of cell-instructive and bactericidal surfaces for bone implants

Recurrent bacterial infection is one of the main reasons of implant failure, hugely impacting the patients’ quality of life, and ultimately resulting in morbidity and even mortality. This type of infection starts with the attachment of the bacteria to the implant surface, leading to biofilm formation and, thus, high resistance against...

The curious case of curvature: Geometric perspectives on biomaterial design

The rapidly expanding field of tissue engineering presents enticing, yet demanding challenges for scientists and engineers across many different disciplines. The ultimate goal of tissue engineering is ambitious: to regenerate damaged or missing tissue in its full complexity, either in vitro or in situ, and restore organ function. In addition to...

Synthesis and evaluation of porous titanium scaffolds prepared with the space holder method for bone tissue engineering

Loss of function and impaired life quality as a result of large bone defects remain a serious problem in the society. Basically, the bone tissue has the capability of healing by itself when fractured. However, impaired healing may occur, leading to delayed union or even non-union when a bone segment is excised above a critical size. In recent...