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Wei, Luxi (author), Wahyulaksana, G. (author), Boni, Enrico (author), Noothout, E.C. (author), Duncker, Dirk J. (author), Tortoli, Piero (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Vos, H.J. (author)Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with...journal article 2023
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Nyns, Emile C.A. (author), Jin, T. (author), Fontes, Magda S. (author), van den Heuvel, Titus (author), Portero, Vincent (author), Bart, Cindy I. (author), Zeppenfeld, Katja (author), Zhang, Kouchi (author), Poelma, René H. (author)AIMS: Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute treatment like electrical cardioversion to restore normal rhythm. Recently, it has been proposed that cardioversion may also be realized via optically controlled generation of bioelectricity by the...journal article 2022
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Heymans, Sophie V. (author), Collado Lara, G. (author), Rovituso, M. (author), Vos, H.J. (author), D'hooge, Jan (author), de Jong, N. (author), Van Den Abeele, Koen (author)Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not...journal article 2022
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Wang, R. (author), Ponsard, Bernard (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β<sup>−</sup> emitters are frequently used in RNT due to the long tissue penetration depth of the β<sup>−</sup> particles....journal article 2022
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Nguyen, M.P. (author)Molecular imaging aims for the visualisation, characterisation, and quantification of biological processes in humans and other living systems at the molecular and cellular level. For today’s patient care, molecular imaging allows for (early) detection and characterisation of disease, efficient planning and assessment of treatments, and...doctoral thesis 2021
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Rahimi, Farzaneh (author), van der Hoek, J.P. (author), Royer, Sebastien (author), Javid, Allahbakhsh (author), Mashayekh-Salehi, Ali (author), Jafari Sani, Moslem (author)Pyrite mine waste was used as a non-toxic and natural catalyst for the activation of peroxydisulfate (PDS) and peroxymonosulfate (PMS) to oxidize tetracycline (TTC), one of the most extensively used antibiotics worldwide, in contaminated water. The results demonstrated that PMS was activated more effectively than PDS by using pyrite....journal article 2021
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Nguyen, M.P. (author), Goorden, M.C. (author), Beekman, F.J. (author)We recently developed a dedicated focusing multi-pinhole collimator for a stationary SPECT system that offers down to 120 m (or 1.7 nL) spatial resolution SPECT images of cryo-cooled tissue samples (EXIRAD-3D). This collimator is suitable for imaging isotopes that are often used in small animal and diagnostic SPECT such as 125I (27 keV),...journal article 2020
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Nguyen, M.P. (author), Ramakers, R.M. (author), Kamphuis, Chris (author), Koustoulidou, Sofia (author), Goorden, M.C. (author), Beekman, F.J. (author)Introduction: Autoradiography is an established technique for high-resolution imaging of radiolabelled molecules in biological tissue slices. Unfortunately, creating a 3D image from a set of these 2D images is extremely time-consuming and error-prone. MicroSPECT systems provide such 3D images but have a low resolution. Here we present EXIRAD...journal article 2020
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Swamy, A. (author), Spliethoff, Jarich W. (author), Burström, Gustav (author), Babic, Drazenko (author), Reich, Christian (author), Groen, Joanneke (author), Edström, Erik (author), Elmi-Terander, Adrian (author), Racadio, John M. (author), Dankelman, J. (author), Hendriks, B.H.W. (author)BACKGROUND: The safe and accurate placement of pedicle screws remains a critical step in open and minimally invasive spine surgery, emphasizing the need for intraoperative guidance techniques. Diffuse reflectance spectroscopy (DRS) is an optical sensing technology that may provide intraoperative guidance in pedicle screw placement. PURPOSE:...journal article 2020
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de Fouw, M. (author), Oosting, R.M. (author), Eijkel, B. I.M. (author), van Altena, P. F.J. (author), Peters, A. A.W. (author), Dankelman, J. (author), Beltman, J. J. (author)Both cryotherapy and thermal ablation are treatment methods for cervical precancerous lesions in screening programs in resource constrained settings. However, for thermal ablation the World Health Organization stated that there is insufficient data to define a standard treatment protocol. This study used an ex-vivo model to compare the tissue...journal article 2020
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French, P.J. (author)In-vivo sensors yield valuable medical information by measuring directly on the living tissue of a patient. These devices can be surface or implant devices. Electrical activity in the body, from organs or muscles can be measured using surface electrodes. For short term internal devices, catheters are used. These include cardiac catheter (in...review 2020
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Vigueras Guillén, J.P. (author), van Rooij, Jeroen (author), Engel, Angela (author), Lemij, Hans G. (author), van Vliet, L.J. (author), Vermeer, K.A. (author)Purpose: To present a fully automatic method to estimate the corneal endothelium parameters from specular microscopy images and to use it to study a one-year follow-up after ultrathin Descemet stripping automated endothelial keratoplasty. Methods: We analyzed 383 post ultrathin Descemet stripping automated endothelial keratoplasty images from...journal article 2020
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Baltussen, Elisabeth J.M. (author), Brouwer de Koning, Susan G. (author), Hendriks, B.H.W. (author), Jóźwiak, Katarzyna (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)In vivo data acquisition using fiberoptic diffuse reflectance spectroscopy (DRS) is more complicated and less controlled compared to ex vivo data acquisition. It would be of great benefit if classifiers for in vivo tissue discrimination based on DRS could be trained on data obtained ex vivo. In this study, in vivo and ex vivo DRS measurements...journal article 2019
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Baltussen, E. J.M. (author), Brouwer de Koning, S. G. (author), Sanders, J. (author), Aalbers, A.G.J. (author), Kok, N. F.M. (author), Beets, G. L. (author), Hendriks, B.H.W. (author), Sterenborg, H. J.C.M. (author), Kuhlmann, K. F.D. (author), Ruers, T. J.M. (author)Background: In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition could be of great benefit in preventing positive resection margins and sparing as much healthy tissue as possible. To better...journal article 2019
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Gaisser, F. (author), Peeters, Suzanne H.P. (author), Lenseigne, B.A.J. (author), Jonker, P.P. (author), Oepkes, Dick (author)A Twin-to-Twin Transfusion Syndrome (TTTS) is a condition that occurs in about 10% of pregnancies involving monochorionic twins. This complication can be treated with fetoscopic laser coagulation. The procedure could greatly benefit from panorama reconstruction to gain an overview of the placenta. In previous work we investigated which steps...journal article 2018
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Vigueras Guillén, J.P. (author), Andrinopoulou, Eleni Rosalina (author), Engel, Angela (author), Lemij, Hans G. (author), van Rooij, J. (author), Vermeer, K.A. (author), van Vliet, L.J. (author)Corneal endothelium images obtained by in vivo specular microscopy provide important information to assess the health status of the cornea. Estimation of clinical parameters, such as cell density, polymegethism, and pleomorphism, requires accurate cell segmentation. State-of-the-art techniques to automatically segment the endothelium are...journal article 2018
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Daeichin, Verya (author), van Rooij, Tom (author), Skachkov, Ilya (author), Ergin, Bulent (author), Specht, Patricia A.C. (author), Lima, Alexandre (author), Ince, Can (author), Bosch, Johan G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)Although high-frequency ultrasound imaging is gaining attention in various applications, hardly any ultrasound contrast agents (UCAs) dedicated to such frequencies (>15 MHz) are available for contrast-enhanced ultrasound (CEUS) imaging. Moreover, the composition of the limited commercially available UCAs for high-frequency CEUS (hfCEUS) is...journal article 2017
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Riool, M. (author), Dirks, A. J. (author), Jaspers, V. (author), Loontjens, T. J.A. (author), van der Loos, C. M. (author), Florquin, S. (author), Apachitei, I. (author), Rijk, L. N.D. (author), Keul, H. A. (author), Zaat, S.A.J. (author)Prevention of biomaterial-associated infections (BAI) remains a challenging problem, in particular due to the increased risk of resistance development with the current antibiotic-based strategies. Metallic orthopaedic devices, such as non-cemented implants, are often inserted under high mechanical stress. These non-cemented implants cannot be...journal article 2017
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Tiruvadi Krishnan, S. (author)All living organisms pass on their genetic information to their offspring in the form of DNA or RNA molecules by duplicating them across generations. In the bacteria, their genes are packed in long chains of DNA molecules or chromosomes. One of the widely studied model organisms, Escherichia coli, replicates its circular chromosome in two...doctoral thesis 2016
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Cueto Rojas, H.F. (author), Maleki Seifar, R. (author), ten Pierick, A. (author), Heijnen, J.J. (author), Wahl, S.A. (author)Ammonium (NH4+) is the most common N-source for yeast fermentations, and N-limitation is frequently applied to reduce growth and increase product yields. While there is significant molecular knowledge on NH4 + transport and assimilation, there have been few attempts to measure the in vivo concentration of this metabolite. In this article, we...journal article 2016
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