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An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritisLesage, Raphaëlle (author), Ferrao Blanco, Mauricio N. (author), Narcisi, Roberto (author), Welting, Tim (author), van Osch, G.J.V.M. (author), Geris, Liesbet (author)Background: Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has...journal article 2022
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Van Steen, Elien (author)During the course of this thesis, the design of a knee brace that improves the quality of life for people with arthritis in the knee, is being researched. The knee joint is covered with articular cartilage which protects the bones from being damaged. Arthritis of the knee is a pathology where this cartilage is damaged potentially even to the...master thesis 2021
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Bakker, Nienke F. (author), Schrijvers, Jim C. (author), van den Noort, Josien C. (author), Hall, Michelle (author), van der Krogt, Marjolein M. (author), Harlaar, J. (author), van der Esch, Martin (author)Background: Patients with knee osteoarthritis can adapt their gait to unload the most painful knee joint in order to try to reduce pain and improve physical function. However, these gait adaptations can cause higher loads on the contralateral joints. The aim of the study was to investigate the interlimb differences in knee and hip frontal...journal article 2021
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Saukko, Annina E.A. (author), Nykänen, Olli (author), Sarin, Jaakko K. (author), Nissi, Mikko J. (author), te Moller, Nikae C.R. (author), Weinans, Harrie (author), Mancini, Irina A.D. (author), Visser, Jetze (author), Brommer, Harold (author)To prevent the progression of posttraumatic osteoarthritis, assessment of cartilage composition is critical for effective treatment planning. Posttraumatic changes include proteoglycan (PG) loss and elevated water content. Quantitative dual-energy computed tomography (QDECT) provides a means to diagnose these changes. Here, we determine the...journal article 2021
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Schrijvers, Jim C. (author), van den Noort, Josien C. (author), van der Esch, Martin (author), Harlaar, J. (author)Knee joint instability is frequently reported by patients with knee osteoarthritis (KOA). Objective metrics to assess knee joint instability are lacking, making it difficult to target therapies aiming to improve stability. Therefore, the aim of this study was to compare responses in neuromechanics to perturbations during gait in patients with...journal article 2021
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Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author)OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...journal article 2021
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Wouda, Frank J. (author), Jaspar, Stephan L.J.O. (author), Harlaar, J. (author), van Beijnum, Bert Jan F. (author), Veltink, Peter H. (author)Background: The foot progression angle is an important measure used to help patients reduce their knee adduction moment. Current measurement systems are either lab-bounded or do not function in all environments (e.g., magnetically distorted). This work proposes a novel approach to estimate foot progression angle using a single foot-worn...journal article 2021
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van Gemert, Y. (author), Kozijn, A. E. (author), Pouwer, M. G. (author), Kruisbergen, N. N.L. (author), van den Bosch, M. H.J. (author), Blom, A.B. (author), Pieterman, E. J. (author), Weinans, Harrie (author), Stoop, R. (author), Princen, H. M.G. (author), van Lent, P. L.E.M. (author)Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE∗3Leiden.CETP mice. Methods:...journal article 2021
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Ferrao Blanco, Mauricio N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Chambers, Mark G. (author), Pitsillides, Andrew A. (author), Narcisi, Roberto (author), van Osch, G.J.V.M. (author)Objective: In osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes to the modification of the extracellular matrix, resulting in permanent cartilage changes. In mouse chondrocytes, pro-inflammatory macrophages and pro-inflammatory cytokines have been shown to stimulate hypertrophy via the activation of the...journal article 2021
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Frints, Ivo (author)Osteoarthritis, the degeneration of articular cartilage, which causes loss of mobility and chronic pain for patients is a common condition with high clinical demand. Care of this condition currently attributes to ±1.4% of the Dutch annual health care costs, but due to the rapidly aging Dutch population a 41% increase of cases is projected over...master thesis 2020
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Bernards, Lotte (author)The implementation of digital innovations is becoming vital in the provision of healthcare. Only this way, issues concerning employee decline and increased demand for care can be tackled. Furthermore, it is seen as the key towards Person Centered Care, a concept where patients and health professionals act as partners. Many digital multi user...master thesis 2020
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Gielis, W. P. (author), Weinans, Harrie (author), Welsing, P. M.J. (author), van Spil, W. E. (author), Agricola, R. (author), Cootes, T. F. (author), de Jong, P. A. (author), Lindner, C. (author)Objective: To design an automated workflow for hip radiographs focused on joint shape and tests its prognostic value for future hip osteoarthritis. Design: We used baseline and 8-year follow-up data from 1,002 participants of the CHECK-study. The primary outcome was definite radiographic hip osteoarthritis (rHOA) (Kellgren–Lawrence grade ≥2...journal article 2020
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Booij, M. J. (author), Richards, R. (author), Harlaar, J. (author), van den Noort, J. C. (author)Objective: To evaluate muscle activation patterns and co-contraction around the knee in response to walking with modified gait patterns in patients with medial compartment knee-osteoarthritis (KOA). Design: 40 medial KOA patients walked on an instrumented treadmill. Surface EMG activity from seven knee-spanning muscles (gastrocnemius,...journal article 2020
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Eenkhoorn, Chantal (author)BACKGROUND: Knee problems are the most common complaints of the lower extremity in the Netherlands. Osteoarthritis has the highest prevalence of all knee complaints. Knee osteoarthritis is likely to start at the patellofemoral joint and is associated with the aggravation of pain. Mechanical overloading is hypothesized to contribute to the...master thesis 2019
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Kozijn, A. E. (author), Tartjiono, M. T. (author), Ravipati, S. (author), van der Ham, F. (author), Barrett, D. A. (author), Mastbergen, S. C. (author), Korthagen, N. M. (author), Lafeber, F. P.J.G. (author), Zuurmond, A. M. (author), Bobeldijk, I. (author), Weinans, Harrie (author), Stoop, R. (author)Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...journal article 2019
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Hirvasniemi, J. (author), Gielis, W. P. (author), Arbabi, S. (author), Agricola, R. (author), van Spil, W. E. (author), Arbabi, V. (author), Weinans, Harrie (author)Objective: To assess the ability of radiography-based bone texture variables in proximal femur and acetabulum to predict incident radiographic hip osteoarthritis (rHOA) over a 10 years period. Design: Pelvic radiographs from CHECK at baseline (987 hips) were analyzed for bone texture using fractal signature analysis (FSA) in proximal femur...journal article 2019
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de Visser, Huub M. (author), Sanchez, Christelle (author), Mastbergen, Simon C. (author), Lafeber, Floris P.J.G. (author), Henrotin, Yves E. (author), Weinans, Harrie (author)Objective: Fibulin-3 is a glycoprotein highly expressed in osteoarthritic cartilage and inhibits angiogenesis and chondrocyte differentiation. Recent studies have indicated that fibulin-3 has potential value as a biomarker in osteoarthritis. The aim of the present study is to examine the role of 3 fibulin-3 peptides (Fib3-1, Fib3-2, and Fib3...journal article 2019
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Venbrux, Justin (author)Taming Esortra is a persuasive game for people diagnosed with osteoarthritis. The two most important symptoms of osteoarthritis are pain and joint stiffness; making it hard and painful for patients to exercise. However, exercise is important and can actually stop the osteoarthritis from getting worse. Taming Esortra uses narrative game-elements...master thesis 2018
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Richards, Rosie E. (author), van den Noort, Josien C. (author), van der Esch, Martin (author), Booij, Marjolein J. (author), Harlaar, J. (author)Background: Gait modifications can reduce the knee adduction moment, a representation of knee loading. Reduced loading may help to slow progression of medial knee osteoarthritis. We aimed to investigate the response of patients with medial knee osteoarthritis to direct feedback on the knee adduction moment as a method for modifying the gait...journal article 2018
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...journal article 2018