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van Heijst, S.E. (author)Two-dimensional (2D) layered materials have attracted the interest of the scientific community following the discovery of graphene and its extraordinary properties. Of particular interest is a class of materials called transition metal dichalcogenides (TMDs). The materials within this class were discovered to show similarly...doctoral thesis 2024
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Park, Junbeom (author), Dutta, Sarmila (author), Sun, Hongyu (author), Jo, Janghyun (author), Karanth, P. (author), Weber, Dieter (author), Tavabi, Amir H. (author), Durmus, Yasin Emre (author), Basak, Shibabrata (author)High energy density electrochemical systems such as metal batteries suffer from uncontrollable dendrite growth on cycling, which can severely compromise battery safety and longevity. This originates from the thermodynamic preference of metal nucleation on electrode surfaces, where obtaining the crucial information on metal deposits in terms...journal article 2024
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4D-STEM Nanoscale Strain Analysis in van der Waals Materials: Advancing beyond Planar ConfigurationsBolhuis, M. (author), van Heijst, S.E. (author), Sangers, J.J.M. (author), Conesa Boj, S. (author)Achieving nanoscale strain fields mapping in intricate van der Waals (vdW) nanostructures, like twisted flakes and nanorods, presents several challenges due to their complex geometry, small size, and sensitivity limitations. Understanding these strain fields is pivotal as they significantly influence the optoelectronic properties of vdW...journal article 2024
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Rhodes, Miriam J. (author), Visscher, A. J. (author), van Keulen, J. (author), Gijsel, Martine A. R. (author)This systematic literature review presents a review of the effects of integrated language arts, science and technology (ILS&T) instruction, with an inquiry- or design-based pedagogy, in elementary schools on student achievement. To this end, an overview of the characteristics of the 19 included studies and their interventions is first...journal article 2024
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van Keulen, J. (author)This philosophical reflection focuses on the ‘T’ of technology in STEM as it appears to stand out as the product or artefact resulting from the practices of science, engineering, and mathematics. This interpretation is enriched by a historical and cultural comparison of technology to ‘techne’, the Greek word for craft that had a deep influence...conference paper 2024
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Bueters, Dorrit (author)Science, Technology, Engineering and Mathematics (STEM) education plays a critical role in personal and societal development by preparing students for a rapidly changing, technological world. However, implementation of integrated STEM education poses significant challenges for educators, particularly in emerging markets such as Kenya, where...master thesis 2023
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de Cocker, Emma (author)The island of Lamu is a part of an archipelago in Kenya’s southeast. In comparison to other parts of Kenya and the rest of the globe, it is a remote and rural area where residents do not have the same access to contemporary educational materials. The Kenya Red Cross Society’s IOMe005 Innovation Hub attempts to combat these disparities by...master thesis 2023
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Zhou, Liangbin (author), Xu, J. (author), Schwab, Andrea (author), Tong, Wenxue (author), Zheng, Lizhen (author), Li, Zhuo (author), Xu, Shunxiang (author), van Osch, G.J.V.M. (author), Wen, Chunyi (author), Qin, Ling (author)As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...review 2023
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- Velot, Émilie (author), Balmayor, Elizabeth R. (author), Bertoni, Lélia (author), Chubinskaya, Susan (author), Cicuttini, Flavia (author), de Girolamo, Laura (author), Demoor, Magali (author), van Osch, G.J.V.M. (author), Cucchiarini, Magali (author) review 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Angelini, Franco (author), Angelini, Pierangela (author), Angiolini, Claudia (author), Bagella, Simonetta (author), Caccianiga, Marco (author), Della Santina, C. (author), Gigante, Daniela (author), Hutter, Marco (author), Nanayakkara, Thrishantha (author)In this paper, we first discuss the challenges related to habitat monitoring and review possible robotic solutions. Then, we propose a framework to perform terrestrial habitat monitoring exploiting the mobility of legged robotic systems. The idea is to provide the robot with the Natural Intelligence introduced as the combination of the...journal article 2023
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Skoupý, R. (author), Boltje, D.B. (author), Slouf, Miroslav (author), Mrázová, Kateřina (author), Láznička, Tomáš (author), Taisne, C.M. (author), Krzyžánek, Vladislav (author), Hoogenboom, J.P. (author), Jakobi, A. (author)A quantitative four-dimensional scanning transmission electron microscopy (4D-STEM) imaging technique (q4STEM) for local thickness estimation across amorphous specimen such as obtained by focused ion beam (FIB)-milling of lamellae for (cryo-)TEM analysis is presented. This study is based on measuring spatially resolved diffraction patterns to...journal article 2023
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Zhu, C. (author), Leung, Chloe Oi Ying (author), Lagoudaki, Eleni (author), Velho, Mariana (author), Segura Caballero, N. (author), Jolles, Dietsje (author), Duffy, Gavin (author), Maresch, Günter (author), Pagkratidou, Marianna (author), Klapwijk, R.M. (author)Empirical interdisciplinary research has explored the role of spatial ability in STEM learning and achievement. While most of this research indicates that fostering spatial thinking in educational contexts has the potential to positively impact students’ enrollment and performance in STEM subjects, there is less agreement on the best approach...review 2023
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Tjernshaugen, Aurora (author)That mechanical properties of the extracellular environment can influence cell behaviour has already been established. Recent studies indicate that human mesenchymal stem cells are affected by the surface curvature of the underlying substrate. However, how meso-scale substrate curvature affects cell behaviour is still not clear. This study...master thesis 2022
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Berenger-Currias, N.M.L.P. (author)Embryogenesis is a fascinating mystery. How a single fertilized egg, the zygote, reads out its genetic information and turns into a fully formed, multicellular organism still defies detailed understanding. <br/>An adult organism can consist of trillions of cells of different types, organized to form various complex tissues and organs. To obtain...doctoral thesis 2022
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Jansen, Marc (author), Fanchamps, L.J.A. (author), Milrad, Marcelo (author), Specht, M.M. (author), Hamidi, Ali (author)One major challenge the educational community is facing relates to how to effectively integrate computational thinking (CT) concepts and ideas into a particular school curriculum. Acquiring CT-skills by means of STEM offers rich opportunities within students´ education which may lead to learning gains. Previous research has shown that, to...conference paper 2022
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Melsen, Janine E. (author), van Ostaijen-ten Dam, Monique M. (author), van den Akker, E.B. (author), Welters, Marij J.P. (author), Heezen, Kim C. (author), Pico-Knijnenburg, Ingrid (author), Kolijn, P.M. (author), Bredius, Robbert G.M. (author), van Doorn, Remco (author)The first successful European hematopoietic stem cell transplantation (HSCT) was performed in 1968 as treatment in a newborn with IL2RG deficiency using an HLA-identical sibling donor. Because of declining naive T and natural killer (NK) cells, and persistent human papilloma virus (HPV)-induced warts, the patient received a peripheral stem...journal article 2022
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Berenger-Currias, N.M.L.P. (author), Mircea, Maria (author), Adegeest, Esmée (author), van den Berg, Patrick R. (author), Feliksik, Marleen (author), Hochane, Mazène (author), Idema, T. (author), Tans, S.J. (author), Semrau, Stefan (author)Stem-cell derived in vitro systems, such as organoids or embryoids, hold great potential for modeling in vivo development. Full control over their initial composition, scalability, and easily measurable dynamics make those systems useful for studying specific developmental processes in isolation. Here we report the formation of gastruloids...journal article 2022
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Neves Leal Costa, B. (author), Adão, Ricardo M.R. (author), Maibohm, Christian (author), Accardo, A. (author), Cardoso, Vanessa F. (author), Nieder, Jana B. (author)Biomimicking biological niches of healthy tissues or tumors can be achieved by means of artificial microenvironments, where structural and mechanical properties are crucial parameters to promote tissue formation and recreate natural conditions. In this work, three-dimensional (3D) scaffolds based on woodpile structures were fabricated by two...journal article 2022