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Castillo Ransanz, Lucía (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...review 2022
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Daneshpour Aryadi, H. (author)Tales of a Fountain of Youth and the invention of medicine illustrate our age-long obsession with two themes: life and death. What it takes to stay alive, and not to be dead, is a basic question in science that is easy to state, and yet difficult to address at a profound level. One striking feature of many living organisms is the ability of...doctoral thesis 2021
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Stevens, L.L. (author)“Teaching is both an art and a science” (Harrison & Coll, 2008 p.1). Good teaching excites students and cultivates their curiosity to learn more than they are asked. But what if students’ blank faces tell you that the teaching did not land, what can you do? Using an analogy or metaphor to explain the principle helps students visualize and...doctoral thesis 2021
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Wagenaar, Kirsten (author)To this day, liver transplantation is the only effective treatment for end-stage liver failure. Unfortunately, the scarcity of liver donors leads to waitlist mortality, pushing the need for alternative treatment options. In vitro models are essential tools in research on alternatives for transplantation. One of the promising models is the...master thesis 2021
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Garmendia Urdalleta, Amaia (author)Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...master thesis 2021
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Berkhout, Willemijn (author)Three-dimensional (3D) bioprinting studies the initial condition of printed constructs, which makes construct static, and neglects the dynamic changes in natural tissue conformation during tissue repair, disease progression and regeneration processes. Therefore, the concept of four-dimensional (4D) bioprinting has been introduced that allows for...master thesis 2021
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Mastrangeli, Massimo (author), van den Eijnden-van Raaij, A.J.M. (author)Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine. The OoC...journal article 2021
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Dostanic, M. (author), Stein, Jeroen (author), Windt, Laura (author), van Meer, Berend (author), Bellin, Milena (author), Orlova, Valeria (author), Mastrangeli, Massimo (author), Mummery, Christine (author), Sarro, Pasqualina M (author)We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties of these tissues. The design of the platform is an anisometrically downscaled version of the Heart-Dyno system, consisting of two elastic micropillars inside...journal article 2020
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Guo, Y. (author)Electron tomography is a powerful tool in materials science to characterize nanostructures in three dimensions (3D). In scanning transmission electron microscopy (STEM), the sample under study is exposed to a focused electron beam and tilted to obtain twodimensional (2D) projections at different angles; many imaging modes are available such as...doctoral thesis 2020
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Watts, Abigail E. (author), Lozinska, Magdalena M. (author), Slawin, Alexandra M.Z. (author), Mayoral, Alvaro (author), Dawson, Daniel M. (author), Ashbrook, Sharon E. (author), Bode, Bela E. (author), Dugulan, A.I. (author), Shannon, Mervyn D. (author)An AlPO<sub>4</sub> zeotype has been prepared using the aromatic diamine 1,10-phenanthroline and some of its methylated analogues as templates. In each case the two template N atoms bind to a specific framework Al site to expand its coordination to the unusual octahedral AlO<sub>4</sub>N<sub>2</sub> environment. Furthermore, using this...journal article 2020
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Sfakianou, Areti (author)Psychiatric disorders are associated with major societal, personal issues and comprise 13% of the global burden of disease. They are heritable and present a complex pathophysiology, characterized by hundreds of genetic variants which are cumulated together and provoke a specific psychiatric disorder. Although a considerable progress has been...master thesis 2019
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Mastrangeli, Massimo (author), Millet, Sylvie (author), ORCHID partners, the (author), van den Eijnden-van Raaij, Janny (author)Organ-on-Chip is considered a potentially game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in...journal article 2019
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Wittig, Corey (author)Pulmonary arterial hypertension (PAH) is a complex, progressive disease characterized by an increased mean pulmonary arterial pressure at rest, and is associated with a high rate of mortality due to right ventricular failure as the disease progresses. While numerous animal and cell culture models have been created in an attempt to better...master thesis 2019
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Mastrangeli, Massimo (author), Millet, Sylvie (author), Mummery, Christine (author), Loskill, Peter (author), Braeken, Dries (author), Eberle, Wolfgang (author), Cipriano, Madalena (author), Fernandez, Luis (author), Graef, M.W.M. (author), Gidrol, Xavier (author), Picollet-D'Hahan, Nathalie (author), van Meer, Berend (author), Ochoa, Ignacio (author), Schutte, Mieke (author), van den Eijnden-van Raaij, Janny (author)This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3...journal article 2019
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Vossen, T.E. (author), Henze, Ineke (author), Rippe, R. C.A. (author), Van Driel, J. H. (author), de Vries, M.J. (author)Research and design activities are important focus points in international policies for secondary Science, Technology, Engineering and Mathematics (STEM) education. It is up to school teachers to implement and supervise these activities in the STEM classroom. However, not much is known about the attitudes teachers hold towards supervising...journal article 2019
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Vossen, T.E. (author), Henze, Ineke (author), de Vries, M.J. (author), van Driel, J.A.S. (author)Research and design activities are becoming more important in Science, Technology, Engineering and Mathematics (STEM) and D&T (design and technology) education. Research and design are often taught separately from each other, while in professional STEM practices, many projects are neither ‘research only’ or ‘design only’—they are both. In...journal article 2019
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Guo, Y. (author), Aveyard, R.A. (author), Rieger, B. (author)In this paper, we present a multichannel cross-modal fusion algorithm to combine two complementary modalities in electron tomography: X-ray spectroscopy and scanning transmission electron microscopy (STEM). The former reveals compositions with high elemental specificity but low signal-to-noise ratio (SNR), while the latter characterizes the...journal article 2019
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Vossen, T.E. (author), Tigelaar, E. H. (author), Henze, Ineke (author), de Vries, M.J. (author), van Driel, J.A.S. (author)Technological design is a core activity in Science, Technology, Engineering and Mathematics (STEM) education. During the design process, students often employ research activities to enhance the quality of their design decisions and to rise above a mere trial-and-error approach to designing. There are many functions of research within the...journal article 2019
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Rahimi, E. (author), Kosari, A. (author), Hosseinpour, S. (author), Davoodi, Ali (author), Zandbergen, H.W. (author), Mol, J.M.C. (author)In this study, we report on a combined microscopic, analytical and electrochemical characterization of the nanoscopic passive layer on a tungsten‑molybdenum-containing super duplex stainless steel. We used scanning transmission electron microscopy/energy dispersive X-ray spectroscopy, scanning Kelvin probe force microscopy, scanning tunneling...journal article 2019
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Croes, M. (author), Kruyt, M. C. (author), Boot, W. (author), Pouran, B. (author), Braham, M. V. (author), Pakpahan, S.A. (author), Weinans, Harrie (author), Vogely, H.C. (author), Fluit, A.C. (author), Dhert, W.J. (author), Alblas, J. (author), Öner, F.C. (author)Immune cells and their soluble factors regulate skeletal cells during normal bone regeneration and pathological bone formation. Bacterial infections can trigger immune responses that activate pro-osteogenic pathways, but these are usually overshadowed by osteolysis and concerns of systemic inflammation. The aim of this study was to determine...journal article 2019