Dissecting the Nucleosome: Single-Molecule Studies of Subnucleosomal Structure and Dynamics

The entire blueprint of all living things is encoded in their genomes, which consist of DNA strands. The genome of a complex organism like ourselves can be several meters long. One of the miracles of nature is that such DNA molecules can be stored in the micron-sized nucleus of eukaryotic cells. For this purpose, the relatively large genome of...

Bacterial chromosome organization by ParB proteins

This thesis explores the mechanisms that underlie chromosome organization in bacteria. Bacteria are considered amongst the simplest living organisms on our planet. They lack the cellular organization found in other domains of life (Archaea or Eukaryotics) and often have simpler life cycles. Over the past decade, we gained increasing knowledge...