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Manoonpong, Poramate (author), Patanè, Luca (author), Xiong, Xiaofeng (author), Brodoline, Ilya (author), Dupeyroux, J.J.G. (author), Viollet, Stéphane (author), Arena, Paolo (author), Serres, Julien R. (author)This review article aims to address common research questions in hexapod robotics. How can we build intelligent autonomous hexapod robots that can exploit their biomechanics, morphology, and computational systems, to achieve autonomy, adaptability, and energy efficiency comparable to small living creatures, such as insects? Are insects good...review 2021
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A Tailor-Made Deazaflavin-Mediated Recycling System for Artificial Nicotinamide Cofactor BiomimeticsDrenth, Jeroen (author), Yang, Guang (author), Paul, C.E. (author), Fraaije, Marco W. (author)Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated form NADP are crucial cofactors for a large array of biocatalytically important redox enzymes. Their high cost and relatively poor stability, however, make them less attractive electron mediators for industrial processes. Nicotinamide cofactor biomimetics (NCBs) are easily...journal article 2021
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Babi, Mouhanad (author), Riesco, Roberto (author), Boyer, Louisa (author), Fatona, Ayodele (author), Accardo, A. (author), Malaquin, Laurent (author), Moran-Mirabal, Jose (author)In nature, cells exist in three-dimensional (3D) microenvironments with topography, stiffness, surface chemistry, and biological factors that strongly dictate their phenotype and behavior. The cellular microenvironment is an organized structure or scaffold that, together with the cells that live within it, make up living tissue. To mimic...journal article 2021
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Godoy Hernandez, A. (author), McMillan, D.G.G. (author)Lipids play a pivotal role in cellular respiration, providing the natural environment in which an oxidoreductase interacts with the quinone pool. To date, it is generally accepted that negatively charged lipids play a major role in the activity of quinone oxidoreductases. By changing lipid compositions when assaying a type II NADH:quinone...journal article 2021
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Van Den Berg, Sander C. (author), Scharff, R.B.N. (author), Rusak, Z. (author), Wu, J. (author)We present a novel DC motor driven soft robotic fish which is optimized for speed and efficiency based on experimental, numerical and theoretical investigation into oscillating propulsion. Our system achieves speeds up to 0.85 m/s, outperforming the previously reported fastest free swimming soft robotic fish by a significant margin of 27%. A...conference paper 2021
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Guarneri, A. (author), Westphal, Adrie H. (author), Leertouwer, C.J. (author), Lunsonga, Joy (author), Franssen, Maurice C.R. (author), Opperman, Diederik J. (author), Hollmann, F. (author), van Berkel, Willem J.H. (author), Paul, C.E. (author)Regioselective aromatic hydroxylation is desirable for the production of valuable compounds. External flavin-containing monooxygenases activate and selectively incorporate an oxygen atom in phenolic compounds through flavin reduction by the nicotinamide adenine dinucleotide coenzyme, and subsequent reaction with molecular oxygen. This study...journal article 2020
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Sideris, Eva Ann (author), De Lange, Hendrik Cornelis (author), Hunt, A. (author)Microfluidic devices and micro-pumps are increasingly necessitated in many fields ranging from untethered soft robots, to pharmaceutical and biomedical technology. While realization of such devices is limited by miniaturization constraints of conventional actuators, these restrictions can be resolved by using smart material transducers...journal article 2020
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Sakes, A. (author), van de Steeg, Ivo A. (author), de Kater, E.P. (author), Posthoorn, P. (author), Scali, M. (author), Breedveld, P. (author)Currently existing tubular transportation systems for the extraction of large tissue masses during Minimal Invasive Surgery (MIS) are subjected to a large amount of operating limitations. In this study, a novel transportation mechanism (patented) was developed inspired by the egg-laying structure of wasps. The developed mechanism consists of...journal article 2020
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Hengst, Madusha (author)In eukaryotic cells, the segregation of nuclear information from the cytosol is carried out by the Nuclear Envelope, a double lipid membrane which protects the genes from cytoplasmic mutagens. To establish a connection between the cytoplasm and nucleoplasm, tiny pores named Nuclear Pore Complexes (NPCs) span through such membrane. The biological...bachelor thesis 2019
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Schmieden, D.T. (author)In this study, a method for the bacterial production of a nacre-mimicking composite material was developed. Nacre (mother-of-pearl) is an organic-inorganic composite found in the inner lining of many mollusk shells and in pearls. It has a brick-and-mortar structure consisting of 95% aragonite (calcium carbonate) platelets and 5% organic matrix....doctoral thesis 2019
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Spiesz, E.M. (author), Schmieden, D.T. (author), Grande, Antonio M. (author), Liang, K. (author), Schwiedrzik, Jakob (author), Natalio, Filipe (author), Michler, Johann (author), Garcia, Santiago J. (author), Aubin-Tam, M.E. (author), Meyer, Anne S. (author)The impressive mechanical properties of natural composites, such as nacre, arise from their multiscale hierarchical structures, which span from nano- to macroscale and lead to effective energy dissipation. While some synthetic bioinspired materials have achieved the toughness of natural nacre, current production methods are complex and...journal article 2019
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Modaresifar, K. (author), Azizian Amiri, S. (author), Ganjian, M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We systematically reviewed the currently available evidence on how the design parameters of surface nanopatterns (e.g. height, diameter, and interspacing) relate to their bactericidal behavior. The systematic search of the literature resulted in 46 studies that satisfied the inclusion criteria of examining the bactericidal behavior of...review 2019
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Josa-Culleré, Laia (author), Lahdenperä, Antti S.K. (author), Ribaucourt, Aubert (author), Höfler, G.T. (author), Gargiulo, S. (author), Liu, Yuan Yang (author), Paradisi, Francesca (author), Hollmann, F. (author), Paul, C.E. (author)Redox reactions catalyzed by highly selective nicotinamide-dependent oxidoreductases are rising to prominence in industry. The cost of nicotinamide adenine dinucleotide coenzymes has led to the use of well-established elaborate regeneration systems and more recently alternative synthetic biomimetic cofactors. These biomimetics are highly...journal article 2019
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Ganjian, M. (author), Modaresifar, K. (author), Ligeon, Manon R.O. (author), Kunkels, Lorenzo B. (author), Tümer, N. (author), Angeloni, L. (author), Hagen, C.W. (author), Otten, L.G. (author), Hagedoorn, P.L. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Development of synthetic bactericidal surfaces is a drug-free route to the prevention of implant-associated infections. Surface nanotopographies with specific dimensions have been shown to kill various types of bacterial strains through a mechanical mechanism, while regulating stem cell differentiation and tissue regeneration. The effective...journal article 2019
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Zhao, Shidi (author), Restrepo Perez, L. (author), Soskine, Misha (author), Maglia, Giovanni (author), Joo, C. (author), Dekker, C. (author), Aksimentiev, A. (author)Ion channels form the basis of information processing in living cells by facilitating the exchange of electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires the development of synthetic ion channels that can alter their conductance in response to a variety of external manipulations....journal article 2019
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van Assenbergh, S.P. (author), Fokker, Marike (author), Langowski, Julian (author), van Esch, J.H. (author), Kamperman, Marleen (author), Dodou, D. (author)The adhesiveness of biological micropatterned adhesives primarily relies on their geometry (e.g., feature size, architecture) and material properties (e.g., stiffness). Over the last few decades, researchers have been mimicking the geometry and material properties of biological micropatterned adhesives. The performance of these biomimetic...journal article 2019
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Stevens, L.L. (author), de Vries, M.J. (author), Bos, Mark M.J.W. (author), Kopnina, Helen (author)The emerging field of biomimicry and learning to design with and for nature has expanded in recent years through a diversity of educational programs. Inspiration following natural forms may give the appearance of being sustainable, but the question remains, how sustainable is it? Misunderstanding the function of these forms may leave...journal article 2019
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Herranz de la Nava, Alba (author)Nature has evolved materials with outstanding mechanical properties, which attain high values of both strength and toughness. The key to their success lies in the combination of hard and soft constituents in a intricate pattern. The design of natural materials allows for the development of toughening mechanisms that increase the overall fracture...master thesis 2018
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Edens, Maike (author)The fracture properties of natural materials often outperform artificial material properties. This could be explained by their complex multi-scale (anisotropic) hard-soft material structure, starting at a nano-scale. The interest in the fabrication of complex biomimetic hard-soft materials and interfaces is growing due to their high fracture...master thesis 2018
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Langowski, Julian K.A. (author), Dodou, D. (author), Kamperman, Marleen (author), van Leeuwen, Johan L. (author)Tree frogs have the remarkable ability to attach to smooth, rough, dry, and wet surfaces using their versatile toe pads. Tree frog attachment involves the secretion of mucus into the pad-substrate gap, requiring adaptations towards mucus drainage and pad lubrication. Here, we present an overview of tree frog attachment, with focus on (i) the...review 2018