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Garner, E. (author)Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the...doctoral thesis 2024
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Zwart, Maarten (author)Over two million bone grafts are performed worldwide, each year. The preferred method is using autografts, but there are two important downsides. There is often insufficient tissue to harvest and the scar at the harvesting side is painfull for the patient. Therefore there exists a great need to improve synthetic grafts.<br/><br/>Traditionally,...master thesis 2024
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Meng, Li (author), Zhao, Panpan (author), Jiang, Yucheng (author), You, Jiawen (author), Xu, Zhiyan (author), Yu, K. (author), Boccaccini, Aldo R. (author), Ma, Junqing (author), Zheng, K. (author)Bioactive glass nanoparticles (BGNs) are well-recognized multifunctional biomaterials for bone tissue regeneration due to their capability to stimulate various cellular processes through released biologically active ions. Understanding the correlation between BGN composition and cellular responses is key to developing clinically usable BGN...journal article 2024
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Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...journal article 2024
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Hulshof, Chantal M. (author), Schallig, Wouter (author), van den Noort, Josien C. (author), Streekstra, Geert J. (author), Kleipool, Roeland P. (author), GG Dobbe, Johannes (author), Maas, Mario (author), Harlaar, J. (author), van der Krogt, Marjolein M. (author)Segment coordinate systems (CSs) of marker-based multi-segment foot models are used to measure foot kinematics, however their relationship to the underlying bony anatomy is barely studied. The aim of this study was to compare marker-based CSs (MCSs) with bone morphology-based CSs (BCSs) for the hindfoot and forefoot. Markers were placed on...journal article 2024
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Rahmani, N. R. (author), Belluomo, R. (author), Kruyt, M. C. (author), Gawlitta, D. (author), Joosten, L. A.B. (author), Weinans, Harrie (author), Croes, M. (author)Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts occur during specific immune training of macrophages that affect their functional state, resulting in heightened (trained) or reduced (tolerant) responses upon exposure to a second stimulus. This is...journal article 2024
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Leerling, Anne T. (author), Smit, Frits (author), Späth, Zita (author), Cañete, Ana Navas (author), de Geus-Oei, L.F. (author), van de Burgt, Alina (author), Dekkers, Olaf M. (author), van der Bruggen, Wouter (author), Appelman-Dijkstra, Natasha M. (author)Chronic nonbacterial osteitis (CNO) is a rare disease spectrum, which lacks biomarkers for disease activity. Sodium fluoride-18 positron emission tomography/computed tomography ([18F]NaF-PET/CT) is a sensitive imaging tool for bone diseases and yields quantitative data on bone turnover. We evaluated the capacities of [18F]NaF-PET/CT to provide...journal article 2024
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van der Plas, Anne-Marijn (author)Immobilisation devices are commonly used for the treatment of extra-articular distal radius fractures. However, conventional immobilisation devices such as plaster casts and fibreglass casts may lead to complications and discomfort. Another disadvantage of present-day conservative fracture treatment is that the casts have to be replaced after...master thesis 2023
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Boetzkes, Jos (author)Background: Minimally invasive cancellous bone biopsy is a common medical procedure in which a needle is used to extract a piece of cancellous bone for examination. Unfortunately, this procedure is not always successful, as sometimes the biopsy can slip partially or completely, necessitating a new biopsy. The occurrence of these errors is not...master thesis 2023
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Putra, N.E. (author)The treatment of large bone injuries continues to be challenging partially due to the limited quantity and quality of bone-replacing materials. Iron (Fe) and its alloys have been developed as a group of load-bearing biomaterials. Recent advances in additive manufacturing (AM) have enhanced the potential of Fe-based biomaterials as biodegradable...doctoral thesis 2023
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Moolenaar, Jet (author)Introduction: Tibial fracture healing complications occur frequently with reported non-union rates up to 23%. Preoperative patient-specific finite element (FE) modelling of fracture fixation may help to minimize these complications. However, developing such models requires labour-intensive work including (manual) segmentation of bones from...master thesis 2023
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Halman, Susanna (author)This thesis presents the research to design a successful high-accuracy, sub-millimetric registration method for an autonomous robot equipped to drill bone for cochlear implant (CI) surgery. Its performance, and thus success, is measured in accuracy, workload, usability and trust. While state-of-the-art (STOTA) research lacks the inclusion of...master thesis 2023
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Ornaghi, Heitor Luiz (author), Monticeli, F.M. (author), Agnol, Lucas Dall (author)n the past decades, there has been a significant increase in the use of polymers for biomedical applications. The global medical polymer market size was valued at USD 19.92 billion in 2022 and is expected to grow at a CAGR of 8.0% from 2023 to 2030 despite some limitations, such as cost (financial limitation), strength compared to metal plates...journal article 2023
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van Hengel, I.A.J. (author), van Dijk, B. (author), Modaresifar, K. (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Leeflang, M.A. (author), Fluit, A.C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additively manufactured (AM) porous titanium implants may have an increased risk of implant-associated infection (IAI) due to their huge internal surfaces. However, the same surface, when biofunctionalized, can be used to prevent IAI. Here, we used a rat implant infection model to evaluate the biocompatibility and infection prevention...journal article 2023
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de Kater, E.P. (author), Müller, R. (author), Sakes, A. (author), Breedveld, P. (author)The fixation strength of pedicle screws could be increased by fixating along the much stronger cortical bone layer, which is not possible with the current rigid and straight bone drills. Inspired by the tsetse fly, a single-plane steerable bone drill was developed. The drill has a flexible transmission using two stacked leaf springs such that...journal article 2023
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Garmendia Urdalleta, A. (author), van Poll, M.A. (author), Fahy, Niamh (author), Witte-Bouma, Janneke (author), van Wamel, Willem (author), Apachitei, I. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Farrell, Eric (author)Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...journal article 2023
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Allahyari, P. (author), Silani, M. (author), Yaghoubi Nasrabadi, V. (author), Milovanovic, P. (author), Schmidt, F. N. (author), Busse, B. (author), Qwamizadeh, M. (author)Bone encompasses a complex arrangement of materials at different length scales, which endows it with a range of mechanical, chemical, and biological capabilities. Changes in the microstructure and characteristics of the material, as well as the accumulation of microcracks, affect the bone fracture properties. In this study, two-dimensional...journal article 2023
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Xu, J. (author), Fahmy-Garcia, Shorouk (author), Wesdorp, Marinus A. (author), Forte, Lucia (author), De Luca, Claudio (author), Filardo, Giuseppe (author), Labberté, Margot (author), Kok, Joeri (author), Nickel, Joachim (author), van Osch, G.J.V.M. (author)Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair potential of this scaffold by adsorbing bone morphogenetic protein 2 (BMP-2) and/or platelet...journal article 2023
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Shi, Z. (author), Su, Q. (author), Kavoura, Dr. Florentia (author), Veljkovic, M. (author)To establish the tensile constitutive model of ultra-high performance concrete containing coarse aggregate (CA-UHPC), monotonic and cyclic uniaxial tensile tests for CA-UHPC with fiber volume fractions of 2.5% and 2.0% were conducted. Test results showed that CA-UHPC exhibits approximately linear stress-strain relation up to the tensile strength...journal article 2023
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Dia, Amadou Sall (author), Renaud, G.G.J. (author), Nooghabi, Aida Hejazi (author), Grimal, Quentin (author)Decreased thickness of the bone cortex due to bone loss in the course of ageing and osteoporosis is associated with reduced bone strength. Cortical thickness measurement from ultrasound images was recently demonstrated in young adults. This requires the identification of both the outer (periosteum) and inner (endosteum) surfaces of the bone...journal article 2023