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Computational design of patient-specific orthopedic implants: from micro-architected materials to shape-matching geometry

Garner, E. (author)

Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the...

doctoral thesis 2024

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Joint simulation made modular and universal: Design of a novel patient and task specific hip kinematic simulation mechanism

van Gemert, Simon (author)

master thesis 2023

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The development of a computational workflow for the semi-automated construction of patient-specific finite element models of tibial fracture fixation

Moolenaar, Jet (author)

Introduction: Tibial fracture healing complications occur frequently with reported non-union rates up to 23%. Preoperative patient-specific finite element (FE) modelling of fracture fixation may help to minimize these complications. However, developing such models requires labour-intensive work including (manual) segmentation of bones from...

master thesis 2023

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3D Printed patient-specific surgical guide with a lateral hinge protecting K-wire and a soft tissue protecting sleeve for open wedge high tibial osteotomy: A pilot study

Renkli, Nagme (author)

Open Wedge High Tibial Osteotomy (OWHTO) is an extensively used, effective treatment option for medical conditions such as medial knee osteoarthritis and varus malalignment. The current developments in the 3D printing industry facilitated using 3D printed patient-specific guides (PSSGs), making OWHTO a desirable treatment option. Although the...

master thesis 2023

document

Towards patient-specific modeling of hearts in children with congenital heart defects: A morphing technique for patient-inspired biventricular models of young hearts in a diverse population

Pentenga, Puck (author)

A congenital heart defect (CHD) is an anomaly in the structure of the heart that is present at birth. In the last 15 years, a CHD is present in 9 per 1,000 live births, making it the most prevalent birth defect (Linde et al., 2011). <br/>CHD’s prevalence coupled with its inherent complexity culminates into situations that are both complicated...

master thesis 2023

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Computational Re-Entry Vulnerability Index Mapping to Guide Ablation in Patients With Postmyocardial Infarction Ventricular Tachycardia

Jelvehgaran Esfahani, M. (author), O'Hara, Ryan (author), Prakosa, Adityo (author), Chrispin, Jonathan (author), Boink, Gerard J.J. (author), Trayanova, Natalia (author), Coronel, Ruben (author), Oostendorp, Thom (author)

Background: Ventricular tachycardias (VTs) in patients with myocardial infarction (MI) are often treated with catheter ablation. However, the VT induction during this procedure does not always identify all of the relevant activation pathways or may not be possible or tolerated. The re-entry vulnerability index (RVI) quantifies regional...

journal article 2023

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Editorial: Image-based computational approaches for personalized cardiovascular medicine: improving clinical applicability and reliability through medical imaging and experimental data

Pirola, S. (author), Arzani, Amirhossein (author), Chiastra, Claudio (author), Sturla, F. (author)

contribution to periodical 2023

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Biomechanical evaluation of additively manufactured patient-specific mandibular cage implants designed with a semi-automated workflow: A cadaveric and retrospective case study

van Kootwijk, A. (author), Jonker, B. P. (author), Wolvius, E. B. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Zhou, J. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Objective: Mandibular reconstruction using patient-specific cage implants is a promising alternative to the vascularized free flap reconstruction for nonirradiated patients with adequate soft tissues, or for patients whose clinical condition is not conducive to microsurgical reconstruction. This study aimed to assess the biomechanical...

journal article 2023

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Design considerations for patient-specific bone fixation plates: a literature review

Brouwer de Koning, S. G. (author), de Winter, N. (author), Moosabeiki, Vahid (author), Mirzaali, Mohammad J. (author), Berenschot, A. (author), Witbreuk, M. M.E.H. (author), Lagerburg, V. (author)

In orthopedic surgery, patient-specific bone plates are used for fixation when conventional bone plates do not fit the specific anatomy of a patient. However, plate failure can occur due to a lack of properly established design parameters that support optimal biomechanical properties of the plate. This review provides an overview of design...

review 2023

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An insertability constraint for shape optimization

Garner, E. (author), Wu, J. (author), Zadpoor, A.A. (author)

Patient-specific implants offer a host of benefits over their generic counterparts. Nonetheless, the design and optimization of these components present several technical challenges, among them being the need to ensure their insertability into the host bone tissue. This presents a significant challenge due to the tight-fitting nature of the...

journal article 2023

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3D printed patient-specific fixation plates for the treatment of slipped capital femoral epiphysis: Topology optimization vs. conventional design

Moosabeiki, Vahid (author), de Winter, N. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Witbreuk, M. M.E.H. (author), Lagerburg, V. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Orthopedic plates are commonly used after osteotomies for temporary fixation of bones. Patient-specific plates have recently emerged as a promising fixation device. However, it is unclear how various strategies used for the design of such plates perform in comparison with each other. Here, we compare the biomechanical performance of 3D...

journal article 2023

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Validation and optimization of Patient-specific orthopedic plate design for proximal femur fixation in slipped capital femoral epiphysis patients

de Winter, Naomi (author)

Slipped capital femoral epiphysis (SCFE) is a condition in adolescents affecting the proximal femur. Increased mechanical forces result in fracture of the growth plate. Factors increasing the mechanical forces include for example obesity and endocrine disorders. As a result of the fracture a shift of the bone shaft towards the femur head occurs,...

master thesis 2022

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Semi-automated digital workflow to design and evaluate patient-specific mandibular reconstruction implants

van Kootwijk, A. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Pahlavani, H. (author), Leeflang, M.A. (author), Kazemivand Niar, S. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zhou, J. (author), Zadpoor, A.A. (author)

The reconstruction of large mandibular defects with optimal aesthetic and functional outcomes remains a major challenge for maxillofacial surgeons. The aim of this study was to design patient-specific mandibular reconstruction implants through a semi-automated digital workflow and to assess the effects of topology optimization on the...

journal article 2022

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Development of a Workflow for Designing Patient-Specific Mandibular Reconstruction Implants and Predicting their Performance through Experimentally Validated Finite Element Models

van Kootwijk, Arthur (author)

Restoration of the normal mandibular form and function is attempted with reconstructive surgery. The current standard procedure to restore continuity defects of the mandible involves free tissue transfer with an autologous bone flap. Even though the success rates are high, several critical drawbacks have been associated with this procedure,...

master thesis 2021

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Development of a 3D Printed Patient-Specific Orthosis for Wrist Immobilization in Long-Term Use

Chung, Jeeyong (author)

Background: Wrist immobilization orthosis is a commonly adopted treatment method for wrist regarding pathologies. In recent years, a group of 3D-printed immobilization orthosis for the upper extremity has been proposed. However, they were mainly developed as substitutes for traditional casts for the upper extremity for short-term usage. There...

master thesis 2021

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Evaluation of the positioning of virtually planned polyetheretherketone patient-specific implants and surgical guides in craniofacial surgery

Nagtegaal, Larissa (author)

Purpose: Patient-specific implants (PSIs) and surgical guides are widely used nowadays for the reconstruction of craniofacial defects. In this research, we quantitatively compared the realised position of craniofacial PSIs with the planned position and we calculated the difference between the realised osteotomy and the planned osteotomy if a...

master thesis 2021

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Effect of sterilization on 3D printed patient-specific surgical guides

van Dal, Vito (author)

Background The current workflow for the design and production of patient-specific surgical guides at the Elisabeth-TweeSteden hospital is out-sourced to external companies, making it a time-consuming and costly task. In order to minimize the production time and expenses, the design and fabrication of these guides could be implemented into the...

master thesis 2021

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Comparison in clinical performance of surgical guides for mandibular surgery and temporomandibular joint implants fabricated by additive manufacturing techniques

Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...

journal article 2021

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3D-Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

Golafshan, Nasim (author), Willemsen, K. (author), Kadumudi, Firoz Babu (author), Vorndran, Elke (author), Dolatshahi-Pirouz, Alireza (author), Weinans, Harrie (author), van der Wal, Bart C.H. (author), Malda, Jos (author), Castilho, Miguel (author)

Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue...

journal article 2021

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Image-based modelling for Adolescent Idiopathic Scoliosis: Mechanistic machine learning analysis and prediction

Tajdari, Mahsa (author), Pawar, Aishwarya (author), Li, Hengyang (author), Tajdari, F. (author), Maqsood, Ayesha (author), Cleary, Emmett (author), Saha, Sourav (author), Zhang, Yongjie Jessica (author), Sarwark, John F. (author), Liu, Wing Kam (author)

Scoliosis, an abnormal curvature of the human spinal column, is characterized by a lateral deviation of the spine, accompanied by axial rotation of the vertebrae. Adolescent Idiopathic Scoliosis (AIS) is the most common type, affecting children between ages 8 to 18 when bone growth is at its maximum rate. We propose a mechanistic machine...

journal article 2021