Monolithic integration of silicon and polymer microstructures for Organ-on-Chip applications

Drug development is a complex, time-consuming (10 - 15 years) and expensive process. For a new medicine to reach the market, the net expenses covered by the pharmaceutical industry have been estimated to be around $2.6 billion. Nevertheless, the risk of finding adverse effects or toxicity cases once the drug is already on the market is still...

Metal and Polymeric Strain Gauges for Si-based, Monolithically Fabricated Organs-on-Chips

Organ-on-chip (OOC) is becoming the alternative tool to conventional in vitro screening. Heart-on-chip devices including microstructures for mechanical and electrical stimulation have been demonstrated to be advantageous to study structural organization and maturation of heart cells. This paper presents the development of metal and polymeric...

Viscoplasticity for instabilities due to strain softening and strain-rate softening

Some observations on element performance in isochoric and dilatant plastic flow

A non-linear finite element approach for the analysis of mode-I free edge delamination in composites

Wave propagation, localization and dispersion in a gradient-dependent medium

Wave propagation and localization in a rate-dependent cracked medium-model formulation and one-dimensional examples