Print Email Facebook Twitter Metal and Polymeric Strain Gauges for Si-based, Monolithically Fabricated Organs-on-Chips Title Metal and Polymeric Strain Gauges for Si-based, Monolithically Fabricated Organs-on-Chips Author Quiros Solano, W.F. (TU Delft Electronic Components, Technology and Materials; Instituto Tecnologico de Costa Rica; BIOND Solutions B.V.) Gaio, N. (TU Delft Electronic Components, Technology and Materials; BIOND Solutions B.V.) Silvestri, C. (BIOND Solutions B.V.) Pandraud, G. (TU Delft EKL Processing) Dekker, R. (TU Delft Electronic Components, Technology and Materials; Philips Research) Sarro, Pasqualina M (TU Delft Electronic Components, Technology and Materials) Date 2019 Abstract Organ-on-chip (OOC) is becoming the alternative tool to conventional in vitro screening. Heart-on-chip devices including microstructures for mechanical and electrical stimulation have been demonstrated to be advantageous to study structural organization and maturation of heart cells. This paper presents the development of metal and polymeric strain gauges for in situ monitoring of mechanical strain in the Cytostretch platform for heart-on-chip application. Specifically, the optimization of the fabrication process of metal titanium (Ti) strain gauges and the investigation on an alternative material to improve the robustness and performance of the devices are presented. The transduction behavior and functionality of the devices are successfully proven using a custom-made set-up. The devices showed resistance changes for the pressure range (0-3 kPa) used to stretch the membranes on which heart cells can be cultured. Relative resistance changes of approximately 0.008% and 1.2% for titanium and polymeric strain gauges are respectively reported for membrane deformations up to 5%. The results demonstrate that both conventional IC metals and polymeric materials can be implemented for sensing mechanical strain using robust microfabricated organ-on-chip devices. Subject CellMembranesMEMSOrgan-on-chipPDMSSiliconStrainStress To reference this document use: http://resolver.tudelft.nl/uuid:503123b4-da08-4e07-a724-800e790f1db0 DOI https://doi.org/10.3390/mi10080536 ISSN 2072-666X Source Micromachines, 10 (8), 1-15 Part of collection Institutional Repository Document type journal article Rights © 2019 W.F. Quiros Solano, N. Gaio, C. Silvestri, G. Pandraud, R. Dekker, Pasqualina M Sarro Files PDF micromachines_10_00536_v2.pdf 21.86 MB Close viewer /islandora/object/uuid:503123b4-da08-4e07-a724-800e790f1db0/datastream/OBJ/view