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Cussen, Kai (author)Thermo-responsive hydrogels are a class of smart material that show increasing promise and applications in the biomedical engineering industry. This thesis investigated a thermo-responsive hydrogel for 4D printing applications. A poly(N-isopropylacrylamide) (>97%) (pNIPAM) based hydrogel was developed and the concentration of NIPAM, as well...master thesis 2024
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Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...journal article 2024
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Li, Jiayu (author), Accardo, A. (author), Liu, Shutian (author)Micro/nanoscale additive manufacturing provides a powerful tool for advanced materials and structures with complex and precise features. For instance, the feature resolution of two-photon polymerization (2PP) can reach 200 nm. At this scale, materials properties can change, and the influence of the size effect cannot be ignored. Therefore, it...journal article 2024
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Yarali, E. (author), Klimopoulou, M. (author), David, M.K. (author), Boukany, P. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)The Poisson's ratio and elastic modulus are two parameters determining the elastic behavior of biomaterials. While the effects of elastic modulus on the cell response is widely studied, very little is known regarding the effects of the Poisson's ratio. The micro-architecture of meta-biomaterials determines not only the Poisson's ratio but...journal article 2024
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Ayman Ahmed Mubeen, AYMAN AHMED MUBEEN (author)Shape morphing is a prevalent feature in all living organisms. Incorporating shape-morphing capabilities into engineered scaffolds in the field of tissue engineering by virtue of 4D printing would allow for structures to closely mimic in-vivo conditions, and dynamically interact with changing cellular microenvironments. Engineered scaffolds...master thesis 2023
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kadel, Himanshu (author)The brain is the most intricate organ in the human body, yet the underlying mechanisms of its cells and networks are not fully mapped. In addition to this lack of understanding, there are numerous neurological disorders and diseases for which a cure remains elusive. There has been persistent research to understand how neuronal cells function...master thesis 2023
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Isaakidou, A. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally...journal article 2023
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Sharaf, A.M.S.E. (author), Frimat, J. P. (author), Kremers, G. J. (author), Accardo, A. (author)Two-photon polymerization (2PP) has provided the field of cell biology with the opportunity to fabricate precisely designed microscaffolds for a wide range of studies, from mechanobiology to in vitro disease modelling. However, a multitude of commercial and in-house developed photosensitive materials employed in 2PP suffers from high auto...journal article 2023
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Akolawala, Q. (author), Keuning, F.E. (author), Rovituso, M. (author), van Burik, Wouter (author), van der Wal, E.M. (author), Versteeg, Henri H. (author), Rondon, Araci M.R. (author), Accardo, A. (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. While X-ray radiotherapy and chemotherapy remain the current standard, proton beam therapy is an appealing alternative as protons can damage cancer cells while sparing the surrounding healthy tissue. However, the effects of protons on in vitro GBM models...journal article 2023
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de Winter, Jikke (author)Biosensing properties like mass, density and stiffness on a single cell level can help diagnose diseases. Mass sensing of cells and subcellular components is typically performed with resonant microstructures. Recently such microstructures were fabricated using an emerging 3D printing technique called two-photon polymerization (2PP) contrary to...master thesis 2022
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Veldkamp, Dian (author)The central nervous system has a very limited capacity to regenerate damaged tissue. Therefore, regeneration strategies focus on transplantation of neural stem cells or differentiated neural cells. In order to make such a treatment effective, it is important to understand the mechanisms that enable cell differentiation. It is well known that...master thesis 2022
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Blankespoor, Maarten (author)The processes that take place within cells are complex. Single-cell analysis is a method that is employed to gain further understanding of the working mechanisms on a single-cellular level. The controlled transport of substances through the cell membrane is important for studying the behaviour and responses of single living cells. Femtopipettes...master thesis 2022
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Sharaf, A.M.S.E. (author), Roos, B. (author), Timmerman, Raissa (author), Kremers, Gert-Jan (author), Bajramovic, Jeffrey John (author), Accardo, A. (author)Microglia are the resident macrophages of the central nervous system and contribute to maintaining brain’s homeostasis. Current 2D “petri-dish” in vitro cell culturing platforms employed for microglia, are unrepresentative of the softness or topography of native brain tissue. This often contributes to changes in microglial morphology, exhibiting...journal article 2022
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Akolawala, Q. (author), Rovituso, M. (author), Versteeg, Henri H. (author), Rondon, Araci M.R. (author), Accardo, A. (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. For this reason, besides clinical and preclinical studies, novel in vitro models for the assessment of cancer response to drugs and radiation are being developed. In such context, three-dimensional (3D)-engineered cellular microenvironments, compared to...journal article 2022
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Neves Leal Costa, B. (author), Adão, Ricardo M.R. (author), Maibohm, Christian (author), Accardo, A. (author), Cardoso, Vanessa F. (author), Nieder, Jana B. (author)Biomimicking biological niches of healthy tissues or tumors can be achieved by means of artificial microenvironments, where structural and mechanical properties are crucial parameters to promote tissue formation and recreate natural conditions. In this work, three-dimensional (3D) scaffolds based on woodpile structures were fabricated by two...journal article 2022
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Roos, Brian (author)Microglia, the resident macrophages of the central nervous system, are key players in neuroinflammation and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. These cells represent promising cellular targets for therapeutic intervention, therefore a detailed cellular biological knowledge of microglia is of paramount importance....master thesis 2021
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Yengül, Damla (author)A research gap exists in a targeted drug delivery into the brain with an implant placed on the outer surface of the cerebral cortex. If an implant with spatial control that can release drugs to a target location can be developed, it will provide efficient treatment opportunities for a variety of brain disorders such as strokes. One of the...master thesis 2021
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Akolawala, Qais (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. Novel <i>in-vitro</i> methods for the assessment of cancer response to drugs and radiation are being developed. Compared to two-dimensional cell culture, three-dimensional cellular microenvironments provide a model closer to the <i>in-vivo</i> situation. In...master thesis 2021
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Tuztaşi, Halis (author)Diamond is known for its outstanding material properties, including highest hardness, excellent chem ical resistance and high thermal conductivity. Diamond, which is normally formed in high pressure and temperature environments, can also be produced as polycrystalline thin films in reduced pressure environments through chemical vapor deposition...master thesis 2021
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Pleeging, R.M.B. (author), Ibis, F. (author), Fan, D. (author), Sasso, L. (author), Eral, H.B. (author), Staufer, U. (author)Detected kidney stone cases are increasing globally, yet knowledge on the conditions for stone formation is lacking. Experimental approaches mimicking the micro-environmental conditions present in vivo can help sci-entists untangle intertwined physiochemical and biological phenomena leading to kidney stone formation. As crystal nucleation often...journal article 2021
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