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Portero, Vincent (author), Deng, Shanliang (author), Boink, Gerard J.J. (author), Zhang, Kouchi (author), de Vries, Antoine (author), Pijnappels, Daniël A. (author)Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, progressive in nature, and known to have a negative impact on mortality, morbidity, and quality of life. Patients requiring acute termination of AF to restore sinus rhythm are subjected to electrical cardioversion, which requires sedation and therefore hospitalization due to...review 2023
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Nyns, Emile C.A. (author), Portero, Vincent (author), Deng, Shanliang (author), Jin, T. (author), Harlaar, Niels (author), Bart, Cindy I. (author), van Brakel, Thomas J. (author), Palmen, Meindert (author), Hjortnaes, Jesper (author), Ramkisoensing, Arti A. (author), Zhang, Kouchi (author), Poelma, René H. (author), Ördög, Balázs (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)Background: Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF), but key translational aspects remain to be studied. Objective: To investigate whether optogenetic cardioversion of AF is effective in the aged heart and whether sufficient light...journal article 2023
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Ördög, Balázs (author), De Coster, Tim (author), Dekker, Sven O. (author), Bart, Cindy I. (author), Zhang, Juan (author), Boink, Gerard J.J. (author), Bax, Wilhelmina H. (author), Deng, Shanliang (author), den Ouden, B.L. (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)To unlock new research possibilities by acquiring control of action potential (AP) morphologies in excitable cells, we developed an opto-electronic feedback loop-based system integrating cellular electrophysiology, real-time computing, and optogenetic approaches and applied it to monolayers of heart muscle cells. This allowed accurate...journal article 2023