Particle detection circuits are used for a wide range of applications from experimental physics to material testing and medical imaging. State-of-the-art imaging systems demand the detection of small amounts of charge with small time-resolution and limited power consumption, creating an implementation dead-end for the typical readout topology. In this thesis, a particle detection readout based on an intersymbol interference cancellation scheme is introduced to address this issue. Evaluated in post-layout simulations, the proposed architecture can detect generated charge as small as 160 aC with 97.8 % certainty. The readout can operate with event-rates up to 400 MEvent/s while only consuming
2.85 mW of power.