The built environment is vulnerable to climate-induced extreme events and natural disasters, which are repeatedly exposing communities to severe consequences and market disruptions. In response, the construction industry is developing resilient technologies for buildings, but the proposed solutions are often not cost-effective, rarely eco-friendly and typically fail to address multiple hazards present in many locations. These shortcomings stem from the absence of a clearly defined framework for quantifying holistic multi-hazard resilience. As a result, investment decisions are ill-informed and technical solutions are sub-optimal. This paper redresses this issue by proposing quantitative indicators and introducing the Resilience Readiness Levels to assess the resilience of buildings, considering multi-domain factors (physical, social, economic, environmental) in single or multi-hazard contexts (heat, seismic, wind, flood). The proposed resilience indices and calculation methods are based on a diverse set of scientific literature and real-world practices, and are demonstrated on Dutch and Italian urban blocks with different local hazards and building layouts. The results show that the multi-domain resilience approach can support informed early-stage building design and retrofit decision-making for single hazards, while aiding prioritization and intervention planning for improving building disaster preparedness in multi-hazard scenarios.