This thesis explores how computational fluid dynamics can be used to predict cross-flow–induced vibrations in tube bundles. The work combines numerical modeling and experimental validation to examine how accurately turbulence models can reproduce the flow behavior and resulting structural response. The project is divided into two phases: a flow-only investigation to assess turbulence modeling approaches, and a coupled fluid–structure phase to predict vibration. The findings show that accurate reproduction of the flow field and excitation forces requires sufficient turbulence resolution and careful numerical treatment. The study highlights both the potential and the limitations of present modeling techniques and provides guidance for future high-fidelity simulations of flow-induced vibrations in complex tube-bundle systems.