ZR

Z. Rahman

4 records found

3D in vitro Cancer Models

Combining Biophysical and Biochemical Cues

In the past decade, cancer cell invasion studies have been mostly performed using single cancer cells. This does not fully recapitulate the tumor physiological properties. Additionally, these studies have poorly recapitulated the wide-ranging extra-cellular matrix (ECM) mechanica ...
Within the tumor microenvironment (TME), cancer cells use mechanotransduction pathways to convert biophysical forces to biochemical signals. However, the underlying mechanisms and functional significance of these pathways remain largely unclear. The upregulation of mechanosensiti ...
An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over c ...
A functional vascular system is a prerequisite for bone repair as disturbed angiogenesis often causes non-union. Paracrine factors released from human bone marrow derived mesenchymal stromal cells (BMSCs) have angiogenic effects on endothelial cells. However, whether these paracr ...