Crossing waterways is crucial to improve transport connections. In particular, new crossing methods are needed when the distance to be covered increases. Submerged Floating Tunnels (SFT) have been recently emerging as a cost-effective feasible crossing technique to connect fjords in Norway. However, only very little research has addressed the vehicle-structure interaction, with attention to the passengers, so far. In the current thesis, an algorithm was developed to study the Fluid-Structure-Vehicle-Interaction (FSVI), where the tunnel has been modelled as a Euler Bernoulli beam, the train car as a 6DOFs system, the supporting cables as linear springs, and the fluid by the Morison's hydrodynamic force expression. The Sperling ride quality and comfort indices were used to address human comfort while crossing the tunnel. It is found that, due to the low-frequency hydrodynamic environment, the influence of the FSVI on the Sperling's indices is limited, i.e. "just noticeable" from the classification table. Low-frequency flow field may cause motion sickness rather than cause comfort/discomfort during the ride. The illness rating, which is the indicator of the motion sickness, gave positive outcomes due to the small amplitude of the accelerations, and therefore no illness is expected to be felt by passengers. This study shows that displacement and acceleration can be controlled and kept inside the proposed boundaries under storm sea states, and the comfort while crossing can be guaranteed. The approach here used can be applied to other sea states with higher frequency content to address the comfort in a storm with smaller return period, which may also be important to address the fatigue resistance of the structure.