In recent years, there has been an increasing need for solutions against the threats that SLR and climate change represent for coastal systems, especially in low lying areas like the SW Dutch coast. Simultaneously, awareness of the impacts that human activities have on natural environments has surged. Integrated and sustainable solutions are necessary. The Delta21 plan proposes an integrated plan for flood-protection, energy storage, and natural ecosystem restoration for The Netherlands, specifically for the Haringvliet estuary. This large-scale intervention will produce large disturbances in the system. Despite the resilient character of tidal basin systems \parencite{Wang2009}, the evaluation of the intervention's effects, in terms of the initial response and the variations in the mechanisms driving morphological changes is compulsory. Assessing the bed level changes is especially important, considering the valuable intertidal and subtidal ecosystems present in the Haringvliet mouth. It is essential to guarantee their preservation despite the large disturbances. The evaluation of the Haringvliet mouth response is performed employing a long-term morphodynamic 2DH computational simulation to forecast the response of the system. The models implemented for the simulation are the Delft3D-FLOW and Delft3D-WAVE. To reduce computational times, the modeling approach applies input reduction and acceleration techniques. The hydraulic forcing is schematized (morphological tide, waves, and discharges) while maintaining the seasonal character of the input. A variable morphological acceleration factor (MF), depending on the wave condition is applied. The variable MF allows us to employ low values during strong-episodic conditions and larger during more regular conditions. The approach is especially beneficial in the presence of oscillating forcings that are also enhanced by the MF. Finally, the impact of the D21 plan on the Haringvliet mouth is assessed by studying the alterations to the hydrodynamic regime, the related net sediment transport pathways, and the observed bed level changes. The analysis of the resulting morphological evolution focuses on the variations of the intertidal and subtidal zones and the mechanisms behind them. We showed that the tidal regime shifts again towards a long-basin regime once the D21 is implemented. The intervention also causes the emergence of new subtidal and intertidal areas, mostly within the Tidal Lake, resulting from the redistribution of the material from the main channel. The original intertidal and subtidal areas, formed by the Hinderplaat and Slikken van Voorne, are almost undisturbed. This behavior guarantees the preservation of the intertidal and subtidal ecosystems. The results also show that despite the initial dredging activity necessary for the D21 plan implementation, which decreases the extent of shallow areas, the emergence of intertidal and subtidal features balances the negative effect as long as no further dredging is performed. The TL shows a net sediment export of material at both control cross-sections (the Haringvliet Dam and the new TL inlet). The findings of the morphological development agree with the known morphology and processes of mixed-energy tidal inlet systems, despite the large-scale intervention. This study provided the opportunity to evaluate the emergence of typical tidal features in a highly disturbed system, where the tidal inlet is shifted further offshore. To achieve an accurate forecast, anthropogenic forcing signals also had to be considered and extrapolated to long-term morphodynamic simulations. The forecasting of large-scale anthropogenic interventions in sensible systems, such as tidal estuaries, is performed successfully by adapting an existing model. The development of this type of study will be increasingly relevant in the future for the evaluation of measures against SLR during conceptual project stages.