During the Bachelor End Project we have been tasked with developing a web portal for the Exposure Render. The Exposure Render is able to interactively visualize volumetric data to photo realistic images. This means that the web portal would allow users to view a visualization of their medical data. The requirements of the web portal have been established through interviews with the client and TU coach. During the process of development an agile methodology was used for the division of tasks and iteratively work towards the end product. From the eight sprints a fully functioning prototype has been developed, which satisfies all the main requirements that had been requested by the client. The prototype is separated into three applications: a web interface for the user, a server for persistent data storage and a container for streaming and controlling the rendered scene by Exposure Render. These applications cooperate to form the requested web portal.

During the preoperative planning for breast-conserving surgery, the surgeon makes use of an MRI scan of the breast cancer patient in the prone position to accurately locate the tumour. However, surgery is performed with the patient in the supine position. The surgeon needs to mentally translate the location of the tumour from the prone position towards the supine position. The usage of mixed reality systems in the form of the Microsoft HoloLens could visually aid the surgeon by projecting the tumour in the supine position onto the patient. This requires us to obtain the tumour in the supine position by dealing with the prone-to-supine breast image registration problem. We propose to maximize the overlap between the prone and supine surfaces of the breast through the use of soft constraints to guide the deformation. An initial subspace FEM simulation pulls the prone and supine surfaces towards each other at specified landmark correspondences between the surfaces. The resulting prone surface is projected onto the supine surface and these surface vertices are restricted to tangential movement across the surface of the breast. The tissues at the interior of the breast are deformed accordingly. Our experiments with synthesized data indicate the robustness of our method under various scenarios, except for the rigid misalignment between the prone and supine meshes. This problem of misalignment also affects the experiments with real-world data, which results in distances greater than 12mmbetween the centroids of the resulting deformed tumour and the ground-truth tumour.