Quantum computers process information stored in quantum bits (qubits), which must be controlled and read out by a traditional electronic interface. Co-designing and cooptimizing such a quantum-classical complex system requires efficient simulators to emulate the qubits and their interaction with classical electronics. For spin-qubit readout, a single electron transistor (SET) is often employed. To build a toolset that can co-simulate the spin qubit system with the classical control and readout interface, a compact and efficient SET model is needed. This paper presents a new compact empirical SET model based on state-of-the-art SET measurement and extracted by a custom function-fitting python program. Within the target source-drain voltage range of ±1000μV , the model is accurate for circuit (SPICE) simulation. Furthermore, the empirical model is represented by a set of equations that enables instantaneous output response requiring a negligible simulation time. With this new SET model, a quantum-electronics co-simulator such as SPINE can now be enhanced to simulate the readout in addition to the control circuits of spin qubits, thus enabling the design of the complete integrated circuit (IC) required for large-scale quantum computers.