On board of High Speed marine Craft (HSC), the crew and the passengers are exposed to high levels of Whole Body Vibrations (WBV) and large magnitude Repeated mechanical Shocks (RS) caused by the motions of the craft. The HSCs are typically 10 meters long, capable of reaching a maximum speed up to 50 knots and widely used by various maritime organizations. However, the operators and crew suffer from fatigue and injuries, leading to a reduced effectiveness and operational capacity of the marine craft. In an attempt to reduce the physical loads, passive Shock Mitigating Seats (SMS) can be installed. Numerous research has shown that an improperly designed SMS may amplify the wave impacts forces through phenomena such as bottoming out and dynamic amplification. Therefore, it is necessary to ensure that a suspension design works properly by testing the performance during wave impact events, before the seat is manufactured and installed onboard the craft. The problem is that it is difficult to determine the performance of the seats in both the design and off-design conditions with either sea trials or laboratory tests. This research focuses on the prevention of injuries and adverse health effects due to repetitive wave impacts by incorporating an injury model in the analyses of various suspension principles in the design of SMS. In the current analyses of SMS either simplistic or specific models are used which restrict the application of these models to other suspension designs. Therefore, a computer program based on the finite element method is developed that allows realistic input accelerations in the surge, heave and pitch direction. The program incorporates highly non-linear elements, including the effect of bottoming. Additionally, the validity of the half-sine approximation for the wave impact excitation pulse was reviewed and concluded to be inappropriate for design purposes as it underestimates the probability of bottoming. Furthermore, the modified evaluation methods of ISO 2631 Part 5 using an optimized age-dependent coefficient based on gender in combination with a Weibull injury risk model were implemented to evaluate the resulting seat level accelerations. A case study was conducted on a Fast Raiding Interception and Special forces Craft (FRISC) of the Royal Netherlands Navy (RNLN). A design based on a parallelogram of pinned truss elements in combination with a coil spring element was altered by replacing the coil spring with a gas-spring element. The design was analysed with dynamic simulations of full-scale measurements of wave impacts on a lifeboat of the Royal Sea Rescue Institution (KNRM). For the most severe wave impact of the acceleration record, the seat level acceleration was reduced from 17.7 [g] to 2.8 [g]. An operator of the age of 24 years who is exposed to the accelerations for half an hour a day, 30 days a year for two consecutive years was assumed. The probability of spinal injury was reduced for a male operator from 99.5% to 16.3% and for a female operator from 100.0% to 42.0%. These results illustrate the high risk of injury to which the HSC operators are exposed. By incorporating highly non-linear elements and spinal injury models, the program and evaluation methods are capable of modelling various SMS suspension designs and analyse the performance. This can assist the seat designer, engineer or researcher with investigating suitable suspension designs before sea trials, experimental tests and prototype iterations. Therefore, the method offers the possibility to save time and reduce costs. Furthermore, the method can assist in defining new regulations in order to limit the exposure of the operators to physical loads and reduce the risk of spinal injury to an acceptable level.