Robots operating alongside people, particularly in sensitive scenarios such as aiding the elderly with daily tasks or collaborating with workers in manufacturing, must guarantee safety and cultivate user trust. Continuum soft manipulators promise safety through material compliance, but as designs evolve for greater precision, payload capacity, and speed, and increasingly incorporate rigid elements, their injury risk resurfaces. In this letter, we introduce a comprehensive High-Order Control Barrier Function (HOCBF) + High-Order Control Lyapunov Function (HOCLF) framework that enforces strict contact force limits across the entire soft-robot body during environmental interactions. Our approach combines a differentiable Piecewise Cosserat-Segment (PCS) dynamics model with a convex-polygon distance approximation metric, named Differentiable Conservative Separating Axis Theorem (DCSAT), based on the soft robot geometry to enable real-time, whole-body collision detection, resolution, and enforcement of the safety constraints. By embedding HOCBFs into our optimization routine, we guarantee safety and actively regulate environmental coupling, allowing, for instance, safe object manipulation under HOCLF-driven motion objectives. Extensive planar simulations demonstrate that our method maintains safety-bounded contacts while achieving precise shape and task-space regulation. This work thus lays a foundation for the deployment of soft robots in human-centric environments with provable safety and performance.

Soft robots promise inherent safety via their material compliance for seamless interactions with humans or delicate environments. Yet, their development is challenging because it requires integrating materials, geometry, actuation, and autonomy into complex mechatronic systems. Despite progress, the field struggles to balance task-specific performance with broader factors like durability and manufacturability—a difficulty that we find is compounded by traditional sequential design processes with their lack of feedback loops. In this perspective, we review emerging co-design approaches that simultaneously optimize the body and brain, enabling the discovery of unconventional designs highly tailored to the given tasks. We then identify three key shortcomings that limit the broader adoption of such co-design methods within the soft robotics domain. First, many rely on simulation-based evaluations focusing on a single metric, while real-world designs must satisfy diverse criteria. Second, current methods emphasize computational modeling without ensuring feasible realization, risking sim-to-real performance gaps. Third, high computational demands limit the exploration of the complete design space. Finally, we propose a holistic co-design framework that addresses these challenges by incorporating a broader range of design values, integrating real-world prototyping to refine evaluations, and boosting efficiency through surrogate metrics and model-based control strategies. This holistic framework, by simultaneously optimizing functionality, durability, and manufacturability, has the potential to enhance reliability and foster broader acceptance of soft robotics, transforming human-robot interactions.