Morphodynamics of world's river deltas are increasingly affected by human activities, which are of great ecological, economic and social implications. However, impacts of human interventions in deltaic regions are insufficiently understood, especially superimposed upon diminishing sediment supplies. This study uses the heavily interfered Yangtze River delta as an example to address this issue. The morphodynamic impacts of the Deepwater Navigation Channel Project (DNCP) during 1997–2013 are investigated through process-based modeling approach (Delft3D) and bathymetric data analysis. The DNCP was implemented in the mouth bar area of the Yangtze River delta including the twin dikes and 19 groynes with the total length of 132.0 km. Hydrodynamic simulations indicate that the training walls resulted in weaker tidal flow and longer slack period at the East Hengsha Shoal (EHS) and stronger tidal flow at the subaqueous delta. Thus, the EHS is characterized as a sediment accumulation zone after the completion of the training walls. Subsequently, morphological modeling shows enhanced accretion at the EHS and enhanced erosion at the subaqueous delta when the training walls are taken into account. Numerical experiments further demonstrate that the above changes are mainly attributed to the seaward half of the northern training walls constructed in 2002–2005. This is probably the reason for the observed accretion peak of the EHS in 2002–2007 and the gradual increase in the erosion rate of the subaqueous delta after 2002. The schematized paths of sediment transport after the DNCP indicate that sediment eroded from the subaqueous delta serves as an important source for accretion of the mouth bar area. It is suggested that siltation promoting projects within the mouth bar area increased shallow shoal accretion and aggravated erosion at the subaqueous delta. With the overall erosion of the Yangtze River delta due to river sediment reduction, large-scale estuarine engineering projects substantially increase the complicacy of its morphodynamic pattern, which merits close attention for sustainable delta management.@en