During offshore construction with a Semi-Submersible Crane Vessel (SSCV) the vessel is station keeping by means of Dynamic Positioning (DP). DP enables a vessel to keep position and heading by utilizing its own propulsion, while being exposed to the environmental forces caused by waves, wind and current. In a comparison study between offshore measurements and time-domain simulations, an increased vessel/thruster response for the offshore measurement was observed. The results revealed, that in operational environmental conditions, the measured vessel response shows increased oscillations in Surge, Sway & Yaw, with periods of approx. 3-5 min. The goal of this thesis was to determine the causes for such an increased dynamic vessel response, which are not captured in time-domain simulations. At present, numerical methods and time-domain simulations that assess the DP performance of a vessel (e.g. aNySIM) assume a quasi-static current of which the variation is only caused by the tides. One thesis is, that time-varying currents on a scale of 1 to 5 minutes can cause an increased vessel response. Furthermore, the DP System as it is used onboard is not captured in aNySIM simulations. This means that the characteristics of the DP System onboard are but not represented in full detail in time-domain simulations. Vortex Induced Motion (VIM) has previously been observed to affect multi column floaters. However, the influence on a SSCV during DP-operations has not yet been studied. In this thesis it was investigated whether the unexpected increased motions originate from time-varying currents, VIM or the DP System itself. A significant challenge was posed to find current measurement data with a small enough time step to confirm the presence of such time-varying currents. One 45 min current measurement with a sampling rate of 1Hz became available. This measurement shows that time-varying currents on a scale of 1 to 5 minutes exist and cannot be assumed to be quasi-static. More research is required to confirm their presence. However, with this limited available data it was shown that time-varying currents can cause an unexpected motion response of a SSCV during DP-operations.In order to obtain the DP System characteristics, a DP Response Amplitude Operator (RAO) assessment was conducted wherein the spring and damping terms were derived as demanded by the controller and as experienced by the vessel. This assessment showed that between 20% to 67% of the demanded critical damping is lost over the control loop of the DP System. These damping losses cause the vessel to overshoot and the damped natural period to decrease. To determine the effects of VIM, current load tests carried out on the hull of an SSCV have been investigated. It was determined that strong currents on column type floaters can cause fluctuating forces and moments that originate from vortex shedding. Further, with real-time simulations it was demonstrated, that also VIM causes an increased, previously unknown, motion response of a SSCV. Lastly, a method was developed to extrapolate the current load test results to velocities below 2kn. Subsequently, in time-domain simulations it was shown that for current velocities above 0.5kn, the vessel experienced forces and moments that caused it to fluctuate around its setpoint.