We live in a world of constant change, driven by human activities that have had an unprecedented impact on our planet’s geology and ecosystems, fundamentally reshaping environments worldwide. Coastal environments, with their complex land-sea, human-nature interactions, are among the most fragile and are constantly under the influence of natural and human processes. For decades, these processes moved in harmony, but as populations grew, so did the demand for resources, land and the development of infrastructure, such as dams, dikes, transport networks and coastal management interventions. The fixation of coastlines and inland systems, driven by contemporary artificial human activity, is an often unintended consequence. The Wadden Sea Region, known for its extensive mudflats, salt marshes and diverse flora and fauna, is an example of how human intervention has had a significant impact on the form and systems of the transition zone between sea and land, or the coastal interface. Over thousands of years, the region has been shaped by the interaction of sea, land and human influences, resulting in a gradient of vital coastal habitats for numerous species and providing many ecosystem services for local and (inter)national economic prosperity. In recent decades, however, human interventions have increasingly altered the region’s coastal interface, largely disrupting the dynamic exchange of energy and materials through land reclamation and infrastructure development. The separation of land and sea has resulted in the loss of the gradual gradients that were once a defining feature of the Wadden Sea Region, along with the region’s identity of ‘living with water’. This has meant the additional loss of vital habitats and ecosystem services provided by the sea for decades, and the overall loss of socio-ecological resilience of the interface system. Now, with the increasing pressures of climate change and human needs on the complex system of the Wadden Sea region, its landscape faces serious challenges now and in the future. A new balance needs to be found between human activities and the conservation and restoration of the unique natural and cultural values of the Wadden Sea Region. The research aims to explore the potential of a new interface framework that restores the landscape gradient between land and sea in harmony with natural processes and cultural values. The intention is to increase the overall social and ecological resilience of the interface system through the development of landscape-based design principles and design interventions, which will be tested at different temporal and spatial scales. The northern Netherlands will serve as a regional test-bed for innovative forms of production and living along the future interface, where the proposed design layout is based on analysis of coastal geomorphological processes, historical practices, landscape structures and existing water structures.