The Akosombo dam in Ghana's Lower Volta River Basin provides essential economic benefits through hydropower generation, flood protection, and irrigation opportunities. However, since its construction was completed in 1965, the livelihood of the riverine communities drastically changed. The seasonal peak and low flows in the river, which provided environmental services for many downstream households, are now replaced with a stable river flow throughout the year to favour hydropower production. A study on dam reoperation is not only of interest to look into the possibilities of restoring healthy ecosystems but also to look at how current water demands in the basin can be sustained. Climate change and increased water demands for irrigation are expected to strain the water resources in the Lower Volta. Reoperation is also complicated by the absence of water treaties with neighbouring countries. This can result in lower flows from upstream riparian states due to their increasing water needs. In this study, we aim to understand the vulnerabilities of the Akosombo system while finding robust policies that can cope with challenging climate and demographic conditions. This study highlights the challenges in balancing irrigation, environmental, and hydropower goals while also identifying system vulnerabilities and opportunities for robust operations to meet the Lower Volta River water demands under future challenging conditions. This is done by reevaluating previously found optimal release policies under uncertainty. From this study, it can be concluded that the uncertainties included in the analysis will alter system functioning. Not only will floods occur with the onset of climate change, but energy production and irrigation potential will also become lower if upstream states start to use more water. The most critical abstractions are those of Togo and Côte d'Ivoire. A benefit of this is that these abstractions also provide some protection against floods. It is therefore wise to create cooperation projects with these countries to safeguard the current benefits of the Akosombo and Kpong dam and create new benefits for all parties.