Positive Energy Districts (PEDs) are integral to achieving sustainable urban development by enhancing energy self-sufficiency and reducing carbon emissions. This paper explores energy balance calculations in four diverse case study districts within different climatic conditions—Fiat Village in Settimo Torinese (Italy), Großschönau (Austria), Beursplain in Amsterdam (Netherlands), and Lunca Pomostului in Reşiţa (Romania)—as part of the SIMPLY Positive project. Each district faces unique challenges, such as outdated infrastructure or heritage protection, which we address through tailored strategies including building renovations and the integration of renewable energy systems. Additionally, we employ advanced simulation methodologies to assess energy performance. Simulation results highlight the significance of innovative technologies like photovoltaic-thermal (PVT) systems, application of demand-side actions, and flexible grid usage. Furthermore, mobility assessments and resident-driven initiatives demonstrate the critical role of community engagement in reducing carbon footprints. This study underscores the adaptability of PED frameworks across varied urban contexts and provides actionable insights for scaling similar strategies globally, supporting net-zero energy targets.