SI
Sébastien Incerti
10 records found
1
GANDALF
Generative ANsatz for DNA damage evALuation and Forecast. A neural network-based regression for estimating early DNA damage across micro-nano scales
Purpose: This study aims to develop a comprehensive simulation framework to connect radiation effects from the microscopic to the nanoscopic scale. Method: The process begins with a Geant4-DNA simulation based on the example ”molecularDNA”, producing a dataset of twelve different
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The early DNA damage on the surface of the Moon due to GCR protons and alpha particles were assessed using a multiscale approach in Geant4. This consisted of three simulation stages. A periodic boundary conditions approach was used to obtain the radiation field on the surface and
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Background: This study aimed to develop a novel human cell geometry for the Geant4-DNA simulation toolkit that explicitly incorporates all 23 chromosome pairs of the human cell. This approach contrasts with the existing, default human cell, geometrical model, which utilizes a con
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Purpose: Based on considerable interest to enlarge the experimental database of radioresistant cells after their irradiation with helium ions, HTB140, MCF-7 and HTB177 human malignant cells are exposed to helium ion beams having different linear energy transfer (LET). Materials a
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Purpose: Interdisciplinary scientific communities have shown large interest to achieve a mechanistic description of radiation-induced biological damage, aiming to predict biological results produced by different radiation quality exposures. Monte Carlo track-structure simulations
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Geant4-DNA example applications for track structure simulations in liquid water
A report from the Geant4-DNA Project
This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path.). These example applications are included in the Geant4
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Mechanistic DNA damage simulations in Geant4-DNA Part 2
Electron and proton damage in a bacterial cell
We extended a generic Geant4 application for mechanistic DNA damage simulations to an Escherichia coli cell geometry, finding electron damage yields and proton damage yields largely in line with experimental results. Depending on the simulation of radical scavenging, electrons do
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Mechanistic DNA damage simulations in Geant4-DNA part 1
A parameter study in a simplified geometry
Mechanistic modelling of DNA damage in Monte Carlo simulations is highly sensitive to the parameters that define DNA damage. In this work, we use a simple testing geometry to investigate how different choices of physics models and damage model parameters can change the estimation
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We report on the recent progress within the Geant4 electromagnetic physics subpackages. Several new interfaces and models recently introduced are already used in LHC applications and may be useful for any type of simulation. Significant developments were carried out to improve th
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