Compound flooding is generated when two or more flood drivers occur simultaneously or in close succession. Multiple drivers can amplify each other and lead to greater impacts than when they occur in isolation. A better understanding of the interdependence between flood drivers would facilitate a more accurate assessment of compound flood risk in coastal regions. This study employed the D-Flow Flexible Mesh model to simulate the historical peak coastal water level, consisting of the storm surge, astronomical tide, and relative sea level rise (RSLR), in Shanghai over the period 1961-2018. It then applies a copula-based methodology to calculate the joint probability of peak water level and rainfall during historical tropical cyclones (TCs) and to calculate the marginal contribution of each driver. The results indicate that the astronomical tide is the leading driver of peak water level, followed by the contribution of the storm surge. In the longer term, the RSLR has significantly amplified the peak water level. This study investigates the dependency of compound flood events in Shanghai on multiple drivers, which helps us to better understand compound floods and provides scientific references for flood risk management and for further studies. The framework developed in this study could be applied to other coastal cities that face the same constraint of unavailable water level records.@en

It has been shown that the proportion of intense tropical cyclones (TCs) has been increasing together with a poleward migration of TC track. However, their relative importance to TC surge at landfall remains unknown. Here we examine the sensitivity of TC surge in Shanghai to landfall location and intensity with a new dynamical modelling framework. We find a surge sensitivity of 0.8 m (°N)−1 to landfall location, and 0.1 m (m s−1)−1 to wind speed in Shanghai during landfall. The landfall location and intensity are comparably important to surge variation. However, based on a plausible range of reported trends of TC poleward migration and intensity, the potential surge hazard due to poleward migration is estimated to be about three times larger than that by intensity change. The long-term surge risk in Shanghai is therefore substantially more sensitive to changes of TC track and landfall location than intensity. This may also be true elsewhere and in the future.@en

In industrial large-scale bioreactors, microorganisms encounter heterogeneous substrate concentration conditions, which can impact growth or product formation. Here we carried out an extended (12 h) experiment of repeated glucose pulsing with a 10-min period to simulate fluctuating glucose concentrations with Aspergillus niger producing glucoamylase, and investigated its dynamic response by rapid sampling and quantitative metabolomics. The 10-min period represents worst-case conditions, as in industrial bioreactors the average cycling duration is usually in the order of 1 min. We found that cell growth and the glucoamylase productivity were not significantly affected, despite striking metabolomic dynamics. Periodical dynamic responses were found across all central carbon metabolism pathways, with different time scales, and the frequently reported ATP paradox was confirmed for this A. niger strain under the dynamic conditions. A thermodynamics analysis revealed that several reactions of the central carbon metabolism remained in equilibrium even under periodical dynamic conditions. The dynamic response profiles of the intracellular metabolites did not change during the pulse exposure, showing no significant adaptation of the strain to the more than 60 perturbation cycles applied. The apparent high tolerance of the glucoamylase producing A. niger strain for extreme variations in the glucose availability presents valuable information for the design of robust industrial microbial hosts.@en

Any dielectric material under a strain gradient presents flexoelectricity. Here, we synthesized 0.75 sodium bismuth titanate −0.25 strontium titanate (NBT-25ST) core–shell nanoparticles via a solid-state chemical reaction directly inside a transmission electron microscope (TEM) and observed domain-like nanoregions (DLNRs) up to an extreme temperature of 800 °C. We attribute this abnormal phenomenon to a chemically induced lattice strain gradient present in the core–shell nanoparticle. The strain gradient was generated by controlling the diffusion of strontium cations. By combining electrical biasing and temperature-dependent in situ TEM with phase field simulations, we analyzed the resulting strain gradient and local polarization distribution within a single nanoparticle. The analysis confirms that a local symmetry breaking, occurring due to a strain gradient (i.e. flexoelectricity), accounts for switchable polarization beyond the conventional temperature range of existing polar materials. We demonstrate that polar nanomaterials can be obtained through flexoelectricity at extreme temperature by tuning the cation diffusion.@en