Jasper V. Been

Journal article (4)

4 records found

First in-human pilot study of wearable phototherapy for neonatal hyperbilirubinaemia

Journal article (2025) - Jessie Spaan (author) , Jasper V. Been (author) , Yanera Wallé (author) , Irwin Reiss (author) , J.H.L. Wagenaar (author) , Christian V. Hulzebos (author) , Berthe A.M. van der Geest (author)

This pilot study aimed to assess the effectiveness and safety of the first wearable phototherapy device in (near-)term neonates with unconjugated hyperbilirubinaemia. This prospective single-arm intervention pilot study was conducted in the Erasmus MC Sophia Children’s Hospital m ...

Spatial, contextual and environmental inequalities in birth outcomes

Journal article (2025) - Anna Suleri (author) , Loes Bertens (author) , Istiaque Ahmed (author) , F.D. van der Hoeven (author) , Eric Steegers (author) , Jasper V. Been (author)

The first 1,000 days of life are a vital period for growth and development, with lasting effects on health and well-being. There is growing recognition of the importance of environmental and societal exposures, like the neighborhood a child is born into. This supports a ‘Health in All Policies’ approach, acknowledging that health is shaped by decisions beyond the healthcare sector. This study explores inequalities in perinatal health across high-risk neighborhoods in the Netherlands, as identified by the Dutch National Program on Safety and Livability (NLPV), focusing on the neighborhoods’ classification rather than their health outcomes. We used nationwide data from Perined (2015-2021) to compare perinatal outcomes among residents of 20 designated NLPV focus areas to other regions (n = 1,118,022 births). Outcomes included perinatal mortality (death from 24 weeks gestation to 7 days after birth), small for gestational age (birthweight <10th percentile), and preterm birth (before 37 weeks). A three-step logistic regression approach was applied: (1) comparing all focus areas combined to the rest of the country, (2) each focus area to the rest of the Netherlands, and (3) each to its municipality. Perinatal mortality (OR 1.13, 95% CI: 1.02-1.24), small for gestational age (OR 1.19, 95% CI: 1.16-1.21), and preterm birth (OR 1.09, 95% CI: 1.06-1.12) were all significantly more prevalent in designated focus areas compared to the rest of the Netherlands. Similar patterns were observed when comparing each designated focus area to other areas as well as to its corresponding municipality. Living in a high-risk neighborhood - defined by safety and livability - is associated with adverse birth outcomes. These findings highlight the need for place-based policy actions to reduce health disparities from the earliest stages of life. Future research will investigate whether local interventions in these specific neighborhoods contribute to improvements in perinatal health outcomes.

Impact assessment of neonatal care interventions on regional neonatal care capacity

A simulation study based on clinical data in the Netherlands

Journal article (2025) - J.H.L. Wagenaar (author) , Alexander Dietz (author) , Yilin Huang (author) , Irwin K.M. Reiss (author) , Jasper V. Been (author) , Jessie Spaan (author) , René F. Kornelisse (author) , Hendrik Rob Taal (author) , S. Hinrichs-Krapels (author)

Objective To analyse the impact of selected neonatal care interventions on regional care capacity.Design Discrete event simulation modelling based on clinical data.

Objective To analyse the impact of selected neonatal care interventions on regional care capacity.

Design Discrete event simulation modelling based on clinical data.

Setting Neonatal care in the southwest of the Netherlands, consisting of one tertiary-level neonatal intensive care unit (NICU), four hospitals with high-care neonatal (HCN) wards and six with medium-care neonatal (MCN) wards.

Participants 44 461 neonates admitted to at least one hospital within the specified region or admitted outside of the region but with a residential address inside the region between 2016 and 2021.

Interventions The impact of three interventions was simulated: (1) home-based phototherapy for hyperbilirubinaemia, (2) oral antibiotic switch for culture-negative early onset infection and (3) changing tertiary-level NICU admission guidelines.

Main outcome measure Regional neonatal capacity defined as: (1) occupancy per ward level, (2) required operational beds per ward level to provide care to all inside region patients at maximum 85% occupancy, (3) proportion rejected, defined as outside region transfers due to no capacity to provide local care and (4) the weekly rejections in relation to occupancy to provide a combined analysis.

Results In the current situation, with many operational beds closed due to nurse shortages, occupancy was extremely high at the NICU and HCNs (respectively 91.7% (95% CI 91.4 to 92.0) and 98.1% (95% CI 98.0 to 98.2)). The number of required beds exceeded available beds, resulting in >20% rejections for both NICU and HCN patients. Although the three interventions individually demonstrated effect on capacity, clinical impact was marginal. In combination, NICU occupancy was reduced below the 85% government recommendation at the cost of an increased burden for HCNs, highlighting the need for redistribution to MCNs.

Conclusion Our model confirmed the severity of current neonatal capacity strain and demonstrated the potential impact of three interventions on regional capacity. The model showed to be a low-cost and easy-to-use method for regional capacity impact assessment and could provide the basis for making informed decisions for other interventions and future scenarios, supporting data-driven neonatal capacity planning and policy development.

Introducing heart rate variability monitoring combined with biomarker screening into a level IV NICU

A prospective implementation study

Journal article (2022) - Şerife Kurul (author) , Nicky van Ackeren (author) , T.G. Goos (author) , Christian R.B. Ramakers (author) , Jasper V. Been (author) , René F. Kornelisse (author) , I. K.M. Reiss (author) , Sinno H.P. Simons (author) , H. R. Taal (author)

The aim of this study was to investigate the association between the implementation of a local heart rate variability (HRV) monitoring guideline combined with determination of inflammatory biomarkers and mortality, measures of sepsis severity, frequency of sepsis testing, and ...