Industrial clusters are facing major challenges in transitioning away from their carbon-intensive activities in order to accelerate the energy transition away from fossil fuels. Therefore, the industrial clusters; the Port of Rotterdam, Chemelot, North-RhineWestphalia (NRW) and Transition System Operator (TSO) GasUnie are planning to develop a pipeline connection for the transportation of renewable fuels between one another (Port of Rotterdam, 2020b). However, this pipeline connection operates in a very uncertain environment with regard to the technology required to decrease greenhouse gas emissions and the future policies that impact on the investment decisions by the industries that will make use of this connection. Therefore, there is much uncertainty about the requirements of the pipeline, making the way in which this new pipeline connection is to be constructed a complex question. Designing a flexible pipeline with capabilities to pro-actively deal with uncertainty could reduce the financial risk and support investment in the pipeline connection. Even so, there is a lack of knowledge about the specific costs and benefits of flexible pipelines and the question arises of how efficiently these flexible pipelines will perform. Therefore, this research is aimed to analyse the performance of various flexible pipeline designs for the connection of Rotterdam, Chemelot and North-Rhine Westphalia and answers the research question:” How do flexible pipeline designs perform for the transportation of sustainable fuels between the Port of Rotterdam, Chemelot and North-Rhine Westphalia from 2025 until 2050?”.