This is D1.5 Functional Requirements of the MEDIATOR project. We are as proud to present this deliverable, regardless of the difficult circumstances under which the task was performed, and we are equally proud because of the difficult circumstances under which this task was performed. Despite this crisis, well beyond our influence and vastly affecting all staff and processes in time and resource unavailability, we have almost naturally maintained our enthusiasm and drive. A crucial success factor for that, is that we have rapidly transformed our once new consortium into a spirited alliance. Credit for that goes to our partners but certainly also to consortium leader SWOV. [...]