Since the outbreak of SARS-COV-2, various virus inactivation techniques have been applied to suppress the spread of virus. Ultraviolet exposure inactivation is an efficient approach to inactivate virus, within UV band, UV-C with comparatively higher energy. UV-C has been proved to inactivate viruses efficiently, while to figure out efficient inactivation approach, virus reduction rate as a function of UV-C wavelength with different viral sensitivity and quantitative exposure dose should be measured through experiments.
On the one hand, miniatured, energy-efficient and fully-customized UV-C light-emitting diodes (LED) offer possibility of switching wavelengths and adjusting quantitative optical properties, on the other hand, UV-C LEDs have been produced with the latest technology based on Aluminium gallium nitride (AlGaN).

~\\Multifunctional UV-C LED Virus Inactivation Experimental Platform is a system designed with replaceable UV-C wavelengths, controllable light intensity and exposure time for quantitative virology experiments. The system has an initial design for standard virology experimental equipment which offers a new and consistent tool for virus researchers. The Inactivation Platform has been assembled and utilized to perform several Influenza A (ssRNA virus) inactivation experiments in order to obtain reduction rate as a function of UV-C wavelength and exposure dose with Germicidal Curve and Inactivation Curve respectively.

~\\After inactivation experiments implementation and result analysis, the inactivation mechanism on the basis of molecular dynamic research theory and simulation is supposed to be figured out. Due to the complexity of proteins in virus, the research focuses on Nucleic Acid Bases (NABs) as target genetic viral material. The absorbed ultraviolet energy results in ultrafast decay, including molecular electronic transition, virus structure variation (Dimerization) theoretically. The absorbed energy along the band is revealed with Absorption Spectrum, and the potential electronic transition depends on the initial structure NABs, together with inside chemical bonds. When absorbed energy populates the molecules to transition state, ultrafast decay takes place because of the existence of Gibbs energy of activation. In the light of molecular dynamic simulation, it proves that compared to ground state, excited state leads to lower standard Gibbs energy of activation, causing higher reaction rate (faster inactivation speed). ... Read more

With the development of biomedical technology such as optogenetics, optoelectronics devices, especially light-emitting diode(LED), becomes wildly used in biomedical researches and applications. Unlike traditional illumination and display applications, biomedical applications have more unique requirements like intensity and response speed. The existing optoelectronics systems cannot fulfill all the requirements of biomedical applications. It is essential to design particular light sources and drivers to fill the blank area of biomedical-compatible optoelectronics systems. However, each biomedical application has its environment and setup. One specific optoelectronics system will not suitable for all circumstances. This work focuses on developing a methodology to design advanced optoelectronics driver systems for biomedical applications to solve this problem. It takes three steps to develop and verify the driver design methodology. The first step is producing a high-power biomedical array driving system to verify the array control strategy. UVC virus inactivation test platform, which successfully finishes virus inactivation test in Erasmus MC, is produced in this step. The second step is extending the array driver to the matrix driver. An interactive optoelectronics system is designed to perform optogenetics experiments in LUMC. Finally, aiming at the ultimate goal-implantable, self-powered driver feasibility research is performed to prove it is feasible to design a self-power optoelectronics driver system in the future. ... Read more