Silicon based device for smart assessment of cellular stiffness
S. Kawasaki (TU Delft - Electrical Engineering, Mathematics and Computer Science)
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Abstract
Cellular stiffness plays an important role for several diseases such as atherosclerosis, malaria and cancer. Cellular stiffness can be derived by the velocity of a cell that is squeezed through a constriction channel. For example, a rigid cell will move slowly through the constriction channel and vice versa. In this research a microfluidic device with integrated electrodes was fabricated to detect the cell within the constriction channel. The velocity of the cell can be measured if the cell is detected at two different location. In this thesis the fabrication process of the device based on standard IC process is presented and electrically characterized.