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Peroxygenase-Catalysed Selective Oxidation of Silanes to Silanols

Journal Article (2023)
Author(s)

Xiaomin Xu (TU Delft - BT/Biocatalysis)

Jacob M.A. van Hengst (TU Delft - BT/Biocatalysis)

Yejia Mao (Student TU Delft)

Mireia Martinez (Barcelona Supercomputing Center)

Sergi Roda (Barcelona Supercomputing Center)

Martin Floor (Barcelona Supercomputing Center)

Victor Guallar (Catalan Institution for Research and Advanced Studies (ICREA), Barcelona Supercomputing Center)

Caroline E. Paul (TU Delft - BT/Biocatalysis)

Miguel Alcalde (Instituto de Catálisis y Petroleoquímica - CSIC)

Frank Hollmann (TU Delft - BT/Biocatalysis)

DOI related publication
https://doi.org/10.1002/anie.202302844 Final published version
More Info
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Publication Year
2023
Language
English
Issue number
24
Volume number
62
Article number
e202302844
Downloads counter
315
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Institutional Repository
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Abstract

A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h−1), catalyst performance (up to 84 s−1 and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme-substrate interaction puts a basis for the mechanistic understanding of AaeUPO selectivity.