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Peroxygenase-Catalysed Selective Oxidation of Silanes to Silanols

Journal Article (2023)
Author(s)

Xiaomin Xu (TU Delft - BT/Biocatalysis)

J.M.A. van Hengst (TU Delft - BT/Biocatalysis)

Yejia Mao (Student TU Delft)

Mireia Martinez (Barcelona Supercomputing Center)

Sergi Roda (Barcelona Supercomputing Center)

Martin Floor (Barcelona Supercomputing Center)

Victor Guallar (Catalan Institution for Research and Advanced Studies (ICREA), Barcelona Supercomputing Center)

C.E. Paul (TU Delft - BT/Biocatalysis)

Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)

Frank Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2023 X. Xu, J.M.A. van Hengst, Yejia Mao, Mireia Martinez, Sergi Roda, Martin Floor, Victor Guallar, C.E. Paul, Miguel Alcalde, F. Hollmann
DOI related publication
https://doi.org/10.1002/anie.202302844
More Info
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Publication Year
2023
Language
English
Copyright
© 2023 X. Xu, J.M.A. van Hengst, Yejia Mao, Mireia Martinez, Sergi Roda, Martin Floor, Victor Guallar, C.E. Paul, Miguel Alcalde, F. Hollmann
Research Group
BT/Biocatalysis
Issue number
24
Volume number
62
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Abstract

A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h−1), catalyst performance (up to 84 s−1 and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme-substrate interaction puts a basis for the mechanistic understanding of AaeUPO selectivity.