Alternating magnetic field and induction heating as antibacterial therapy in implant-associated infections
M. Salandova (TU Delft - Biomaterials & Tissue Biomechanics)
E.L. Fratila-Apachitei (TU Delft - Biomaterials & Tissue Biomechanics)
I. Apachitei (TU Delft - Biomaterials & Tissue Biomechanics)
A.A. Zadpoor (Leiden University Medical Center, TU Delft - Biomaterials & Tissue Biomechanics)
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Abstract
OBJECTIVE: The treatment of mature biofilm in implant-associated infections (IAI) has become increasingly challenging, mainly due to the rise of antibiotic-resistant bacteria. While many antibacterial biomaterials harness their functionality through their surface properties, alternating magnetic field (AMF)-induced hyperthermia offers an approach from a fundamentally different angle. METHOD: To summarize and compare the practice of assessing AMF-induced hyperthermia in vitro and in vivo as treatment for implant-associated infections and the efficacy of this therapy, a literature search was conducted and 18 articles were selected based on relevance. RESULTS AND CONCLUSION: The studies have demonstrated that AMF-induced hyperthermia can effectively eliminate biofilms as a standalone treatment or in combination with antimicrobials. Although thermal tissue damage is an inherent concern, it can be controlled and reduced by implementing short intermittent heating patterns around 65-75ºC while still preserving antibacterial efficacy. However, clear guidelines for evaluating safety, particularly regarding thermal injury, are still lacking and should be a key focus of future work.
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