Two contrast detection sequences for bandwidth-limited intravascular ultrasound transducers
David Maresca (Erasmus MC)
Guillaume Renaud (Erasmus MC)
Gijs Van Soest (Erasmus MC)
Xiang Li (University of Southern California)
Qifa Zhou (University of Southern California)
K. Kirk Shung (University of Southern California)
Nico De Jong (ImPhys/Acoustical Wavefield Imaging , University of Southern California, Erasmus MC)
Antonius F.W. Van Der Steen (ImPhys/Acoustical Wavefield Imaging , Erasmus MC)
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Abstract
Atherosclerosis is associated with the formation of microvessels in the arterial wall, referred to as vasa vasorum (VV). VV imaging may constitute a new intravascular ultrasound (IVUS) metric of coronary artery plaque vulnerability. The potential of nonlinear contrast IVUS to detect VV in vivo was demonstrated using a prototype transducer with dual-peak frequency response. In this study, we report the feasibility of pulse-inversion ultraharmonic IVUS contrast imaging and6 chirp reversal contrast IVUS imaging. Their performance is compared for VV detection. Both sequences operate with limited transducer bandwidths (<60%), and are therefore implementable on clinical IVUS catheters.