DM

D. Maresca

12 records found

PROTEUS

A Physically Realistic Contrast-Enhanced Ultrasound Simulator—Part II: Imaging Applications

The development of new imaging paradigms in the field of contrast-enhanced ultrasound (CEUS) is hindered by the difficulty to control complex experimental variables in a laboratory setting, such as vascular geometries, nonlinear ultrasound wave propagation in tissue, or microbubb ...

Nonlinear sound-sheet microscopy

Imaging opaque organs at the capillary and cellular scale

Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluorescent reporters limit this method to studying thin or translucent specimens. In this ...
The past decade has seen an increasing number of technological advances to interface with single neurons and neuronal circuits being applied in vivo. These methods have greatly accelerated our understanding of neural pathways in the brain in health and disease. Additionally, thes ...

PROTEUS

A Physically Realistic Contrast-Enhanced Ultrasound Simulator—Part I: Numerical Methods

Ultrasound contrast agents (UCAs) have been used as vascular reporters for the past 40 years. The ability to enhance vascular features in ultrasound images with engineered lipid-shelled microbubbles has enabled breakthroughs such as the detection of tissue perfusion or super-reso ...
The field of contrast-enhanced ultrasound (CEUS) combines nonlinearly oscillating microbubbles (MBs) with dedicated pulse sequences to reveal the vascular function of organs. Clinical ultrasound contrast agents consist of polydisperse MB suspensions with diameters ranging from 0. ...
The influence of the transducer lens on image reconstruction is often overlooked. Lenses usually exhibit a lower sound speed than soft biological tissues. In academic research, the exact lens sound speed and thickness are typically unknown. Here we present a simple and nondestruc ...
Gas vesicles are gas-filled nanocompartments that allow a diverse group of bacteria and archaea to control their buoyancy. The molecular basis of their properties and assembly remains unclear. Here, we report the 3.2 Å cryo-EM structure of the gas vesicle shell made from the stru ...
Ultrasound localization microscopy (ULM) is a vascular imaging method that provides a 10-fold improvement in resolution compared to ultrasound Doppler imaging. Because typical ULM acquisitions accumulate large numbers of synthetic microbubble (MB) trajectories over hundreds of ca ...
Ultrasound imaging is one of the most widely used modalities in clinical practice, revealing human prenatal development but also arterial function in the adult brain. Ultrasound waves travel deep within soft biological tissues and provide information about the motion and mechanic ...
Visualizing biomolecular and cellular processes inside intact living organisms is a major goal of chemical biology. However, existing molecular biosensors, based primarily on fluorescent emission, have limited utility in this context due to the scattering of light by tissue. In c ...

Publisher Correction

Acoustic biosensors for ultrasound imaging of enzyme activity (Nature Chemical Biology, (2020), 16, 9, (988-996), 10.1038/s41589-020-0591-0)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Atherosclerosis is associated with the formation of microvessels in the arterial wall, referred to as vasa vasorum (VV). VV imaging may constitute a new intravascular ultrasound (IVUS) metric of coronary artery plaque vulnerability. The potential of nonlinear contrast IVUS to det ...