Microelectromechanical Organs-on-Chip
Massimo Mastrangeli (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Hande Aydogmus (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Milica Dostanic (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Paul Motreuil-Ragot (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Nele Revyn (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Bjorn de Wagenaar (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Ronald Dekker (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Pasqualina M. Sarro (TU Delft - Electrical Engineering, Mathematics and Computer Science)
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Abstract
Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap in drug development, and possibly foster personalized medicine. Here we underline the biotechnological convergence at the root of OoC technology, and outline research tracks under development in our group at TU Delft along two main directions: fabrication of innovative microelectromechanical OoC devices, integrating stimulation and sensing of tissue activity, and their embedding within advanced platforms for pre-clinical research. We conclude with remarks on the role of open technology platforms for the broader establishment of OoC technology in pre-clinical research and drug development.