Microelectromechanical Organs-on-Chip

Conference paper (2021)

Authors

Massimo Mastrangeli Electronic Components, Technology and Materials - EEMCS
H. Aydogmus Electronic Components, Technology and Materials - EEMCS
M. Dostanic Electronic Components, Technology and Materials - EEMCS
P.A. Motreuil-Ragot Electronic Components, Technology and Materials - EEMCS
N. Revyn Electronic Components, Technology and Materials - EEMCS
B. de Wagenaar Electronic Components, Technology and Materials - EEMCS
R. Dekker Electronic Components, Technology and Materials - EEMCS
Pasqualina M Sarro Electronic Components, Technology and Materials - EEMCS
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
Copyright: © 2021 Massimo Mastrangeli, H. Aydogmus, M. Dostanic, P.A. Motreuil-Ragot, N. Revyn, B. de Wagenaar, R. Dekker, Pasqualina M Sarro
DOI: https://doi.org/10.1109/Transducers50396.2021.9495646
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Published Date

2021

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap in drug development, and possibly foster personalized medicine. Here we underline the biotechnological convergence at the root of OoC technology, and outline research tracks under development in our group at TU Delft along two main directions: fabrication of innovative microelectromechanical OoC devices, integrating stimulation and sensing of tissue activity, and their embedding within advanced platforms for pre-clinical research. We conclude with remarks on the role of open technology platforms for the broader establishment of OoC technology in pre-clinical research and drug development.

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