Proteases in bacteriophage defense systems and their potential in bioengineering
Konstantinos Kalogeropoulos (TU Delft - BN/Stan Brouns Lab, Kavli institute of nanoscience Delft, University of Denmark)
Sam P.B. van Beljouw (Kavli institute of nanoscience Delft, TU Delft - BN/Stan Brouns Lab)
Dani Feldmann (Student TU Delft, Kavli institute of nanoscience Delft)
Daan F. van den Berg (TU Delft - BN/Stan Brouns Lab, Kavli institute of nanoscience Delft)
Stan J.J. Brouns (Kavli institute of nanoscience Delft, TU Delft - BN/Stan Brouns Lab)
More Info
expand_more
Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.
Abstract
Novel phage defense systems featuring diverse enzymatic activities are continually being discovered. Among these, defense systems employing proteolytic enzymes have been identified, revealing a previously unrecognized enzymatic activity in phage defense. These protease-associated defense systems represent an untapped reservoir for new biotechnological tools and may serve as a springboard for the development of proteome editors. This review outlines recent advancements in the discovery and characterization of protease-containing defense systems, proposes methods for further exploration and investigation of protease activity, and considers the prospect of protease defense systems for modulating protein processing and cell fate.
help_outline