Print Email Facebook Twitter On the Versatility of Nanozeolite Linde Type L for Biomedical Applications Title On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and in Vivo Positron Emission Tomography Study Author Lacerda, Sara (CNRS) Zhang, W. (TU Delft BT/Biocatalysis) T. M. De Rosales, Rafael (King’s College London) Da Silva, Isidro (Université d'Orléans) Sobilo, Julien (CNRS) Lerondel, Stéphanie (CNRS) Tóth, Éva (CNRS) Djanashvili, K. (TU Delft BT/Biocatalysis; CNRS) Date 2022 Abstract Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (GdIII) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 (89Zr). Thereby, exploiting 89Zr-chloride resulted in a slightly higher radiolabeling in the inner cavities compared to the commonly used 89Zr-oxalate, which apparently remained on the surface of LTL. Intravenous injection of PEGylated 89Zr/GdIII-LTL in healthy mice allowed for PET-computed tomography evaluation, revealing initial lung uptake followed by gradual migration of LTL to the liver and spleen. Ex vivo biodistribution confirmed the in vivo stability and integrity of the proposed multimodal probe by demonstrating the original metal/Si ratio being preserved in the organs. These findings reveal beneficial biological behavior of the nanozeolite LTL and hence open the door for follow-up theranostic studies by exploiting the immense variety of metal-based radioisotopes. Subject multimodal imagingnanozeolitespositron emission tomography (PET)radiolabelingradiopharmaceuticalszirconium-89 To reference this document use: http://resolver.tudelft.nl/uuid:94683dab-562d-44ca-891d-409792891758 DOI https://doi.org/10.1021/acsami.2c03841 ISSN 1944-8244 Source ACS applied materials & interfaces, 14, 32788-32798 Part of collection Institutional Repository Document type journal article Rights © 2022 Sara Lacerda, W. Zhang, Rafael T. M. De Rosales, Isidro Da Silva, Julien Sobilo, Stéphanie Lerondel, Éva Tóth, K. Djanashvili Files PDF acsami.2c03841.pdf 6 MB Close viewer /islandora/object/uuid:94683dab-562d-44ca-891d-409792891758/datastream/OBJ/view