Exploration and exploitation of the uncommon pH profile of the dynamic covalent interactions between boronic acids and N-acetylneuraminic acids

Peters, J.A.; Djanashvili, K.

doi:10.1016/j.ccr.2023.215254

Exploration and exploitation of the uncommon pH profile of the dynamic covalent interactions between boronic acids and N-acetylneuraminic acids

Title

Exploration and exploitation of the uncommon pH profile of the dynamic covalent interactions between boronic acids and N-acetylneuraminic acids

Author

Peters, J.A. (TU Delft BT/Biocatalysis)
Djanashvili, K. (TU Delft BT/Biocatalysis)

Date

2023

Abstract

In this review, the chemical mechanisms behind the interactions between boronic acids and N-acetylneuraminic acids, which have been widely utilized in biomedicine in recent decades, will be examined. It will also be highlighted that the affinity of boronic acids for N-acetylneuraminic acids is dependent on pH and is complementary to their affinity for other common monosaccharides found in glycocalyces. Through various examples from the literature, the unique pH profile of the boronic – N-acetylneuraminic acids acid interaction and its uses in biomedicine will be illustrated.

Subject

Boronic acids
Boronic esters
Drug carriers
Sialic acids
Targeted drug delivery
Targeted tumor therapy
Tumor markers

To reference this document use:

http://resolver.tudelft.nl/uuid:dfb65f02-54bd-4db3-9bd1-c9d75f2dd3c9

DOI

https://doi.org/10.1016/j.ccr.2023.215254

ISSN

0010-8545

Source

Coordination Chemistry Reviews, 491

Part of collection

Institutional Repository