Searched for: author%3A%22Peters%2C+J.A.%22
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Peters, J.A. (author), Djanashvili, K. (author)
In this review, the chemical mechanisms behind the interactions between boronic acids and N-acetylneuraminic acids, which have been widely utilized in biomedicine in recent decades, will be examined. It will also be highlighted that the affinity of boronic acids for N-acetylneuraminic acids is dependent on pH and is complementary to their...
review 2023
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Geraldes, Carlos F.G.C. (author), Castro, M. Margarida C.A. (author), Peters, J.A. (author)
journal article 2022
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Geraldes, Carlos F.G.C. (author), Peters, J.A. (author)
Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the...
review 2022
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Geraldes, Carlos F.G.C. (author), Castro, M. Margarida C.A. (author), Peters, J.A. (author)
Mn(III) porphyrins have great potential as Gd-free MRI contrast agents because both the cation and the ligand have interesting properties. The redox properties of the Mn(III)-ion can be exploited for the preparation of reactive oxygen species for therapy. Moreover, the porphyrin ligand allows these complexes to have a high affinity for tumor...
review 2021
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Carvalho, Rui F.S. (author), Pereira, Giovannia A.L. (author), Rocha, João (author), Castro, M. Margarida C.A. (author), Granadeiro, Carlos M. (author), Nogueira, Helena I.S. (author), Peters, J.A. (author), Geraldes, Carlos F.G.C. (author)
The NMR relaxivities of the decatungstolanthanoate core-shell nanoparticles, prepared by encapsulating [Ln(W<sub>5</sub>O<sub>18</sub>)<sub>2</sub>]<sup>9−</sup> polyoxometalates (LnPOM) within amorphous silica shells (K<sub>9</sub>[Ln(W<sub>5</sub>O<sub>18</sub>)<sub>2</sub>]@SiO<sub>2</sub>), were studied along the Ln series. The relaxivity...
journal article 2021
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Peters, J.A. (author)
Manganese ferrite nanoparticles are superparamagnetic and have very high saturation magnetization, which makes them candidates for application as MRI contrast agents. Because these nanoparticles are very effective enhancers of transverse relaxation, they are particularly suitable as negative (T<sub>2</sub>-weighted) contrast agents. The...
review 2020
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Peters, J.A. (author), Djanashvili, K. (author), Geraldes, Carlos F.G.C. (author), Platas-Iglesias, Carlos (author)
In the periodical system, the lanthanides (the 15 elements in the periodic table between barium and hafnium) are unique in the sense that their trivalent cations have their valence electrons hidden behind the 5s and 5p electrons. They show a gradual decrease in ionic radius with increasing atomic number (also known as the lanthanide...
review 2020
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Peters, J.A. (author), Geraldes, Carlos F.G.C. (author)
A semi-empirical equation to estimate the hydration number of Mn(II) complexes was derived from a database of 49 previously published <sup>1</sup>H longitudinal Nuclear Magnetic Relaxation Dispersion profiles. This equation has the longitudinal <sup>1</sup>H relaxivity and the molecular weight of the Mn(II) complex under consideration as...
journal article 2018
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Peters, J.A. (author), van Bekkum, H. (author)
book chapter 2017
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Zhang, W. (author), Martinelli, J. (author), Peters, J.A. (author), van Hengst, Jacob M.A. (author), Bouwmeester, Hans (author), Kramer, Evelien (author), Bonnet, Celia S. (author), Szeremeta, Frederic (author), Toth, Eva (author), Djanashvili, K. (author)
Surface PEGylation of nanoparticles designed for biomedical applications is a common and straightforward way to stabilize the materials for in vivo administration and to increase their circulation time. This strategy becomes less trivial when MRI active porous nanomaterials are concerned as their function relies on water/proton-exchange between...
journal article 2017
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Peters, J.A. (author)
Synthetic variable temperature <sup>1</sup>H NMRD profiles and <sup>17</sup>O NMR relaxation and shift data were generated with a model based on the Solomon-Bloembergen-Morgan and Freed theories and then fitted simultaneously or individually. The effects of the fitting procedure and of experimental uncertainties on the resulting best-fit...
journal article 2016
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Geraldes, C.F.G.C. (author), Djanashvili, K. (author), Peters, J.A. (author)
Recently, many research activities in medical diagnosis have been devoted to molecular imaging with MRI. A key issue is the evaluation of molecular targets that allow the early detection and characterization of diseases and the assessment of the effects of therapy. The majority of the current targeting vectors are peptides and proteins; reports...
journal article 2010
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Schühle, D.T. (author), Van Rijn, P. (author), Laurent, S. (author), Van der Elst, L. (author), Muller, R.N. (author), Stuart, M.C.A. (author), Schatz, J. (author), Peters, J.A. (author)
Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.
journal article 2010
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Schühle, D.T. (author), Polášek, M. (author), Lukeš, I. (author), Chauvin, T. (author), Tóth, E. (author), Schatz, J. (author), Hanefeld, U. (author), Stuart, M.C.A. (author), Peters, J.A. (author)
A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect to its suitability as MRI contrast agent. The compound forms spherical micelles in water with a cmc of 35 mMand a radius of 8.2 nm. The relaxivity of these aggregates is 31.2 s-1 mM-1 at 25ºC and...
journal article 2009
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Prata, M.I.M. (author), Ribeiro, M.J. (author), Santos, A.C. (author), Peters, J.A. (author), Nepveu, F. (author), Geraldes, C.F.G.C. (author), De Lima, J.J.P. (author)
Aiming at radiopharmaceutical application, I111n3+ complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of I111n(TTHA)3- and I111n(TTHA-bis(butylamide)- was evaluated by measuring the exchange of I111n3+ from the complexes to transferrin and the results were compared...
journal article 1998
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Van den Berg, R. (author), Peters, J.A. (author), Van Bekkum, H. (author)
Abstract of NL 9301614 (A) The invention relates to a method for the selective oxidative degradation of saccharides, wherein the oxidation is carried out with a peroxide, preferably hydrogen peroxide, in a basic medium in the presence of boric acid or a borate. The starting compound is preferably a saccharide which forms less stable borate...
patent 1995
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Peters, J.A. (author)
doctoral thesis 1978
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