Print Email Facebook Twitter Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: A potential MRI contrast agent Title Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: A potential MRI contrast agent Author Schühle, D.T. Poláek, M. Luke, I. Chauvin, T. Tóth, E. Schatz, J. Hanefeld, U. Stuart, M.C.A. Peters, J.A. Faculty Applied Sciences Department Biotechnology Date 2009-10-26 Abstract A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect to its suitability as MRI contrast agent. The compound forms spherical micelles in water with a cmc of 35 mMand a radius of 8.2 nm. The relaxivity of these aggregates is 31.2 s-1 mM-1 at 25ºC and 20 MHz, which corresponds to a molecular relaxivity of 125 s-1 mM-1. The high relaxivity mainly originates from the short tM (72.7 ns) and the size of the micelles. The interaction with bovine serum albumin (BSA) was studied and an observed relaxivity of up to 40.8 s-1 mM-1 (163.2 s-1 mM-1 per binding place) at 20 MHz and 37ºC was found in the presence of 2.0 mM protein. To reference this document use: http://resolver.tudelft.nl/uuid:6c8dee22-dd69-46c4-87d3-08cf80b9c580 DOI https://doi.org/10.1039/b917673j Publisher Royal Society of Chemistry Embargo date 2010-10-01 ISSN 1477-9226 Source Dalton Transactions, 39, 2010 Part of collection Institutional Repository Document type journal article Rights (c) 2010 The Author(s); Royal Society of Chemistry Files PDF Schuehle2_2010.pdf 266.39 KB Close viewer /islandora/object/uuid:6c8dee22-dd69-46c4-87d3-08cf80b9c580/datastream/OBJ/view