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Chen, Honghao (author), Lu, Ruofei (author), Gao, Yixun (author), Yue, Xiaorui (author), Yang, Haihong (author), Li, Hao (author), Lee, Yi Kuen (author), French, P.J. (author), Wang, Yao (author), Zhou, Guofu (author)Inspired by the CO<sub>2</sub>-induced reversible activation mechanism of the slow anion channel 1 (SLAC1) in plant stomatal guard cells during plant photosynthesis, we designed and prepared a CO<sub>2</sub>- switchable H<sup>+</sup>/OH<sup>−</sup> ion channel (CSPH ion channel). A high-performance chemiresistive room temperature CO<sub>2<...journal article 2023
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Liu, Xiangcheng (author), Niu, Yue (author), Jin, Duo (author), Zeng, Junwei (author), Li, Wanjiang (author), Li, Hao (author), Lee, Yi Kuen (author), French, P.J. (author), Wang, Yao (author)Transition metal dichalcogenides (TMDCs) garner significant attention for their potential to create high-performance gas sensors. Despite their favorable properties such as tunable bandgap, high carrier mobility, and large surface-to-volume ratio, the performance of TMDCs devices is compromised by sulfur vacancies, which reduce carrier...journal article 2023
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Liang, Hongping (author), Guo, Xin (author), Guo, Lanpeng (author), Liu, Siying (author), Zhan, Qiuqiang (author), Yang, Haihong (author), Li, Hao (author), de Rooij, Nicolaas Frans (author), Lee, Yi Kuen (author), French, P.J. (author), Wang, Yao (author), Zhou, Guofu (author)Constructing near-infrared light (NIR) light-enhanced room temperature gas sensors is becoming more promising for practical application. In this study, learning from the structure and photosynthetic process of chlorophyll thylakoid membranes in plants, the first “Thylakoid membrane” structural formaldehyde (HCHO) sensor is constructed by...journal article 2023
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Liu, Ke (author), Tan, C. (author), Li, Shizhen (author), Yuan, Wucheng (author), Liu, X. (author), Zhang, Kouchi (author), French, P.J. (author), Ye, H. (author), Wang, S. (author)This paper proposes and simulates research on the reverse recovery characteristics of two novel superjunction (SJ) MOSFETs by adjusting the doping profile. In the manufacturing process of the SJ MOSFET using multilayer epitaxial deposition (MED), the position and concentration of each Boron bubble can be adjusted by designing different doping...journal article 2023
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Rapid Fabrication of High-Performance Flexible Pressure Sensors Using Laser Pyrolysis Direct WritingWang, S. (author), Zong, Qihang (author), Yang, Huiru (author), Tan, C. (author), Huang, Qianming (author), Liu, X. (author), Zhang, Kouchi (author), French, P.J. (author), Ye, H. (author)The fabrication of flexible pressure sensors with low cost, high scalability, and easy fabrication is an essential driving force in developing flexible electronics, especially for high-performance sensors that require precise surface microstructures. However, optimizing complex fabrication processes and expensive microfabrication methods...journal article 2023
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Mai, Zhijian (author), Cao, Nengjie (author), Cheng, Erzhuo (author), Zeng, Zhiwen (author), Feng, Yancong (author), Wang, Yao (author), French, P.J. (author), Lee, Yi Kuen (author), Yang, Haihong (author)To develop multifunctional small-molecule prodrugs is highly desirable for cancer treatment but remains challenging in intrinsic traceability. As an acid-cleavable linkage, a Schiff bases benefiting from its distinctive fluorescence quenching ability was selected to prepare a small-molecule prodrug with cancer-targeted and self-indicating. In...journal article 2023
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van der Voort, Sebastian R. (author), Incekara, Fatih (author), Wijnenga, Maarten M.J. (author), Kapsas, Georgios (author), Schouten, J.W. (author), French, P.J. (author), Niessen, W.J. (author), Smits, M. (author), Klein, Stefan (author)BACKGROUND: Accurate characterization of glioma is crucial for clinical decision making. A delineation of the tumor is also desirable in the initial decision stages but is time-consuming. Previously, deep learning methods have been developed that can either non-invasively predict the genetic or histological features of glioma, or that can...journal article 2023
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Hoogstrate, Youri (author), Draaisma, Kaspar (author), Barin, N. (author), Taphoorn, Martin J.B. (author), Weyerbrock, Astrid (author), Sanson, Marc (author), Hoeben, Ann (author), Lukacova, Slávka (author), Lombardi, Giuseppe (author), Hanse, Monique (author), Fleischeuer, Ruth E.M. (author), Watts, Colin (author), Angelopoulos, Nicos (author), Gorlia, Thierry (author), Robe, Pierre A. (author), French, P.J. (author)A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an...journal article 2023
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Guo, Lanpeng (author), Liang, Hongping (author), Hu, Huiyun (author), Shi, Shenbin (author), Wang, Chenxu (author), Li, Hao (author), Lee, Yi Kuen (author), French, P.J. (author), Wang, Yao (author)Achieving convenient and accurate detection of indoor ppb-level formaldehyde is an urgent requirement to ensure a healthy working and living environment for people. Herein, ultrasmall In<sub>2</sub>O<sub>3</sub> nanorods and supramolecularly functionalized reduced graphene oxide are selected as hybrid components of visible-light-driven (VLD)...journal article 2023
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Wang, S. (author), Yang, Huiru (author), Zong, Qihang (author), Huang, Qianming (author), Tan, C. (author), Gao, Chenshan (author), Li, Shizhen (author), Ye, H. (author), Zhang, Kouchi (author), French, P.J. (author)In recent years, metal crack-based stretchable flexible strain sensors have attracted significant attention in wearable device applications due to their extremely high sensitivity. However, the tradeoff between sensitivity and detection range has been an intractable dilemma, severely limiting their practical applications. Herein, we propose a...journal article 2023
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Wang, Jianqiang (author), Gao, Yixun (author), Chen, Fengjia (author), Zhang, Lulu (author), Li, Hao (author), De Rooij, Nicolaas Frans (author), Umar, Ahmad (author), Lee, Yi Kuen (author), French, P.J. (author)Implementing parts per billion-level nitric oxide (NO) sensing at room temperature (RT) is still in extreme demand for monitoring inflammatory respiratory diseases. Herein, we have prepared a kind of core-shell structural Hemin-based nanospheres (Abbr.: Hemin-nanospheres, defined as HNSs) with the core of amorphous Hemin and the shell of...journal article 2022
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Guo, Yuanyuan (author), Wang, Quan (author), LI, H. (author), Gao, Yixun (author), Xu, Xuezhu (author), Tang, Biao (author), Yang, B. (author), Lee, Yi Kuen (author), French, P.J. (author)Fluorescent patterns with multiple functions enable high-security anti-counterfeiting labels. Complex material synthesis and patterning processes limit the application of multifunctional fluorescent patterns, so the technology of in situ fluorescent patterning with tunable multimodal capabilities is becoming more necessary. In this work, an...journal article 2022
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French, P.J. (author), Krijnen, Gijs JM (author), Vollebregt, S. (author), Mastrangeli, Massimo (author)Silicon sensors date back to before 1960 with early Hall and piezoresistive devices. These used simple processing that was part of the early integrated circuit (IC) industry. As the IC industry developed, silicon sensors could benefit from the technological advances. As silicon sensors advanced, there came the need for new technologies...journal article 2022
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de Graaf, G. (author), Vriesendorp, Maurits Frans (author), Amin Hassan, H.M. (author), French, P.J. (author)In this research fluorescent optochemical pH probes for the detection of ischaemia have been investigated. Myocardial ischaemia is the most prominent risk during heart surgery. During open heart surgery the heart is temporarily arrested and, since there no blood flowing, oxygen supply and removal of waste products is stopped and heart cells...journal article 2022
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Gao, Yixun (author), Wang, Jianqiang (author), Feng, Yancong (author), Cao, Nengjie (author), Li, Hao (author), de Rooij, Nicolaas Frans (author), Umar, Ahmad (author), French, P.J. (author), Wang, Yao (author), Zhou, Guofu (author)It is a great challenge to develop efficient room-temperature sensing materials and sensors for nitric oxide (NO) gas, which is a biomarker molecule used in the monitoring of inflammatory respiratory diseases. Herein, Hemin (Fe (III)-protoporphyrin IX) is introduced into the nitrogen-doped reduced graphene oxide (N-rGO) to obtain a novel...journal article 2022
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Barin, N. (author), Balcioglu, Hayri E. (author), de Heer, Iris (author), de Wit, Maurice (author), Lamfers, Martine L.M. (author), van Royen, Martin E. (author), French, Pim J. (author), Accardo, A. (author)A major obstacle in glioma research is the lack of in vitro models that can retain cellular features of glioma cells in vivo. To overcome this limitation, a 3D-engineered scaffold, fabricated by two-photon polymerization, is developed as a cell culture model system to study patient-derived glioma cells. Scanning electron microscopy, (live...journal article 2022
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Steijlen, A.S.M. (author), Jansen, K.M.B. (author), Bastemeijer, J. (author), French, P.J. (author), Bossche, A. (author)Sweat sensors allow for new unobtrusive ways to continuously monitor an athlete's performance and health status. Significant advances have been made in the optimization of sensitivity, selectivity, and durability of electrochemical sweat sensors. However, comparing the in situ performance of these sensors in detail remains challenging because...journal article 2022
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Steijlen, A.S.M. (author), Bastemeijer, J. (author), Nederhoff, R.J. (author), Jansen, K.M.B. (author), French, P.J. (author), Bossche, A. (author)Ammonium levels in sweat can potentially be used to measure muscle fatigue and to diagnose particular metabolic myopathies. To research the potential use of ammonia in sweat as a biomarker, a new real-time monitoring system is developed. This system consists of a capsule that is placed on the skin and ventilated with dry air. A metal-oxide...journal article 2021
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Steijlen, A.S.M. (author), Burgers, D.B.J. (author), Wilmes, Erik (author), Bastemeijer, J. (author), Bastiaansen, Bram J.C. (author), French, P.J. (author), Bossche, A. (author), Jansen, K.M.B. (author)This article presents a novel smart sensor garment with integrated miniaturized inertial measurements units (IMUs) that can be used to monitor lower body kinematics during daily training activities, without the need of extensive technical assistance throughout the measurements. The smart sensor tights enclose five ultra-light sensor modules that...journal article 2021
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Steijlen, A.S.M. (author), Bastemeijer, J. (author), Groen, Pim (author), Jansen, K.M.B. (author), French, P.J. (author), Bossche, A. (author)This paper presents a method to continuously collect and reliably measure sweat analyte concentrations during exercise. The method can be used to validate newly developed sweat sensors and to obtain insight into intraindividual variations of sweat analytes in athletes. First, a novel design of a sweat collection system is created. The sweat...journal article 2020